ArticleGenetics2009
Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- HP1a-mediated heterochromatin formation promotes antimicrobial responses against Pseudomonas aeruginosa infection.BMC biology · 2022Article
- Insights into HP1a-Chromatin Interactions.Cells · 2020Review
- A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation.Nature cell biology · 2019Article
- Article
- Maternal Proteins That Are Phosphoregulated upon Egg Activation Include Crucial Factors for Oogenesis, Egg Activation and Embryogenesis inG3 (Bethesda, Md.) · 2018Article
- Induction of H3K9me3 and DNA methylation by tethered heterochromatin factors inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Article
- The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila.Genetics · 2016Article
- Histone variants and epigenetics.Cold Spring Harbor perspectives in biology · 2015Review
- A role for MeCP2 in switching gene activity via chromatin unfolding and HP1γ displacement.PloS one · 2013Article
- The epigenetic H3S10 phosphorylation mark is required for counteracting heterochromatic spreading and gene silencing in Drosophila melanogaster.Journal of cell science · 2011Article
- H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing.Epigenetics & chromatin · 2011Article
- Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity.PLoS genetics · 2011Article
- Chromatin higher-order structure and dynamics.Cold Spring Harbor perspectives in biology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Centric regions of eukaryotic genomes are packaged into heterochromatin, which possesses the ability to spread along the chromosome and silence gene expression. The process of spreading has been challenging to study at the molecular level due to repetitious sequences within centric regions. A heterochromatin protein 1 (HP1) tethering system was developed that generates "ectopic heterochromatin" at sites within euchromatic regions of the Drosophila melanogaster genome. Using this system, we show that HP1 dimerization and the PxVxL interaction platform formed by dimerization of the HP1 chromo shadow domain are necessary for spreading to a downstream reporter gene located 3.7 kb away. Surprisingly, either the HP1 chromo domain or the chromo shadow domain alone is sufficient for spreading and silencing at a downstream reporter gene located 1.9 kb away. Spreading is dependent on at least two H3K9 methyltransferases, with SU(VAR)3-9 playing a greater role at the 3.7-kb reporter and dSETDB1 predominately acting at the 1.9 kb reporter. These data support a model whereby HP1 takes part in multiple mechanisms of silencing and spreading.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.