ArticleAntimicrobial agents and chemotherapy2009
Stability of peroxide antimalarials in the presence of human hemoglobin.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Kinetic Study and Reaction Mechanism of the Gas-Phase Thermolysis Reaction of Methyl Derivatives of 1,2,4,5-Tetroxane.Molecules (Basel, Switzerland) · 2024Article
- Antileishmanial Anthracene Endoperoxides: Efficacy In Vitro, Mechanisms and Structure-Activity Relationships.Molecules (Basel, Switzerland) · 2022Article
- Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance.Antimicrobial agents and chemotherapy · 2022Article
- Advances in the research on the targets of anti-malaria actions of artemisinin.Pharmacology & therapeutics · 2020Review
- Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress inAntioxidants (Basel, Switzerland) · 2020Article
- Oxidation of Erythrocytes Enhance the Production of Reactive Species in the Presence of Artemisinins.International journal of molecular sciences · 2020Article
- Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials ImpactsAntimicrobial agents and chemotherapy · 2018Article
- Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production.Protoplasma · 2016Review
- Stability of the antimalarial drug dihydroartemisinin under physiologically relevant conditions: implications for clinical treatment and pharmacokinetic and in vitro assays.Antimicrobial agents and chemotherapy · 2015Article
- The molecular mechanism of action of artemisinin--the debate continues.Molecules (Basel, Switzerland) · 2010Review
- Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.Nature reviews. Microbiology · 2009Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peroxide antimalarials, including artemisinin, are important for the treatment of multidrug-resistant malaria. These peroxides are known to react with iron or heme to produce reactive intermediates that are thought to be responsible for their antimalarial activities. This study investigated the potential interaction of selected peroxide antimalarials with oxyhemoglobin, the most abundant form of iron in the human body. The observed stability of artemisinin derivatives and 1,2,4-trioxolanes in the presence of oxyhemoglobin was in contrast to previous reports in the literature. Spectroscopic analysis of hemoglobin found it to be unstable under the conditions used for previous studies, and it appears likely that the artemisinin reactivity reported in these studies may be attributed to free heme released by protein denaturation. The stability of peroxide antimalarials with intact oxyhemoglobin, and reactivity with free heme, may explain the selective toxicity of these antimalarials toward infected, but not healthy, erythrocytes.
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