ArticleSchizophrenia research2009
Abnormal expression of myelination genes and alterations in white matter fractional anisotropy following prenatal viral influenza infection at E16 in mice.
Article in Schizophrenia research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Pooled it
- Granular cytoplasmic inclusions in astrocytes and microglial activation in the fetal brain of pigtail macaques in response to maternal viral infection.Acta neuropathologica communications · 2025Article
- Involvement of virus infections and antiviral agents in schizophrenia.Psychological medicine · 2025Review
- Extracellular free water elevations are associated with brain volume and maternal cytokine response in a longitudinal nonhuman primate maternal immune activation model.Molecular psychiatry · 2023Article
- Characterisation of the consequences of maternal immune activation on distinct cell populations in the developing rat spinal cord.Journal of anatomy · 2022Article
- Nonrespiratory sites of influenza-associated disease: mechanisms and experimental systems for continued study.The FEBS journal · 2022Review
- Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring.Brain, behavior, & immunity - health · 2021Article
- Newborn white matter microstructure moderates the association between maternal postpartum depressive symptoms and infant negative reactivity.Social cognitive and affective neuroscience · 2020Article
- Schizophrenia and Influenza at the Centenary of the 1918-1919 Spanish Influenza Pandemic: Mechanisms of Psychosis Risk.Frontiers in psychiatry · 2020Review
- Poly(I:C) Challenge Alters Brain Expression of Oligodendroglia-Related Genes of Adult Progeny in a Mouse Model of Maternal Immune Activation.Frontiers in molecular neuroscience · 2020Article
- Neonatal influenza virus infection affects myelination in influenza-recovered mouse brain.Journal of veterinary science · 2018Article
- The neurobiology of transition to psychosis: clearing the cache.Journal of psychiatry & neuroscience : JPN · 2017Article
- Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia.Translational psychiatry · 2017Review
- The effects of prenatal H1N1 infection at E16 on FMRP, glutamate, GABA, and reelin signaling systems in developing murine cerebellum.Journal of neuroscience research · 2017Article
- Dietary supplementation with n-3 fatty acids from weaning limits brain biochemistry and behavioural changes elicited by prenatal exposure to maternal inflammation in the mouse model.Translational psychiatry · 2015Article
- Decreased Na(+) influx lowers hippocampal neuronal excitability in a mouse model of neonatal influenza infection.Scientific reports · 2015Article
- Brain in flames - animal models of psychosis: utility and limitations.Neuropsychiatric disease and treatment · 2015Review
- Peptide sharing between influenza A H1N1 hemagglutinin and human axon guidance proteins.Schizophrenia bulletin · 2014Article
- Pre-clinical models of neurodevelopmental disorders: focus on the cerebellum.Reviews in the neurosciences · 2014Review
- Altered microstructural connectivity of the superior cerebellar peduncle is related to motor dysfunction in children with autistic spectrum disorders.Cerebellum (London, England) · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Prenatal viral infection has been associated with the development of schizophrenia and autism. Our laboratory has previously shown that viral infection causes deleterious effects on brain structure and function in mouse offspring following late first trimester (E9) and late second trimester (E18) administration of influenza virus. We hypothesized that middle second trimester infection (E16) in mice may lead to a different pattern of brain gene expression and structural defects in the developing offspring. C57BL6 mice were infected on E16 with a sublethal dose of human influenza virus or sham-infected using vehicle solution. Male offspring of the infected mice were collected at P0, P14, P35, and P56, their brains removed and cerebella dissected and flash frozen. Microarray, DTI and MRI scanning, as well as qRT-PCR and SDS-PAGE and western blotting analyses were performed to detect differences in gene expression and brain atrophy. Expression of several genes associated with myelination, including Mbp, Mag, and Plp1 were found to be altered, as were protein levels of Mbp, Mag, and DM20. Brain imaging revealed significant atrophy in cerebellum at P14, reduced fractional anisotropy in white matter of the right internal capsule at P0, and increased fractional anisotropy in white matter in corpus callosum at P14 and right middle cerebellar peduncle at P56. We propose that maternal infection in mouse impacts myelination genes.
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Registered trials
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