ArticleBiophysical journal2009
Axial tubules of rat ventricular myocytes form multiple junctions with the sarcoplasmic reticulum.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
- From function to structure: how myofibrillogenesis influences the transverse-axial tubular system development and its peculiarities.Frontiers in physiology · 2025Review
- Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers.The Journal of general physiology · 2024Article
- 3D structured illumination microscope using a spinning disk [Invited].Biomedical optics express · 2023Article
- Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Nanoscale Organization, Regulation, and Dynamic Reorganization of Cardiac Calcium Channels.Frontiers in physiology · 2021Review
- Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes.Circulation. Heart failure · 2020Article
- Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy.ACS nano · 2019Article
- Dynamic and Irregular Distribution of RyR2 Clusters in the Periphery of Live Ventricular Myocytes.Biophysical journal · 2018Article
- Dyadic Plasticity in Cardiomyocytes.Frontiers in physiology · 2018Review
- Shining New Light on the Structural Determinants of Cardiac Couplon Function: Insights From Ten Years of Nanoscale Microscopy.Frontiers in physiology · 2018Review
- Calcium release-dependent inactivation precedes formation of the tubular system in developing rat cardiac myocytes.European biophysics journal : EBJ · 2017Article
- T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure.Cardiovascular research · 2017Article
- Sarcoplasmic reticulum is an intermediary of mitochondrial and myofibrillar growth at the intercalated disc.Journal of muscle research and cell motility · 2016Article
- Distribution and Function of Cardiac Ryanodine Receptor Clusters in Live Ventricular Myocytes.The Journal of biological chemistry · 2015Article
- Transitions of protein traffic from cardiac ER to junctional SR.Journal of molecular and cellular cardiology · 2015Article
- Mechanisms of SR calcium release in healthy and failing human hearts.Biophysical reviews · 2015Article
- Revealing T-Tubules in Striated Muscle with New Optical Super-Resolution Microscopy Techniquess.European journal of translational myology · 2015Review
- Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1).Circulation research · 2014Article
- Analysis of tubular membrane networks in cardiac myocytes from atria and ventricles.Journal of visualized experiments : JoVE · 2014Article
- Functional cardiac imaging by random access microscopy.Frontiers in physiology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ryanodine receptors (RyRs) are located primarily on the junctional sarcoplasmic reticulum (SR), adjacent to the transverse tubules and on the cell surface near the Z-lines, but some RyRs are on junctional SR adjacent to axial tubules. Neither the size of the axial junctions nor the numbers of RyRs that they contain have been determined. RyRs may also be located on the corbular SR and on the free or network SR. Because determining and quantifying the distribution of RyRs is critical for both understanding and modeling calcium dynamics, we investigated the distribution of RyRs in healthy adult rat ventricular myocytes, using electron microscopy, electron tomography, and immunofluorescence. We found RyRs in only three regions: in couplons on the surface and on transverse tubules, both of which are near the Z-line, and in junctions on most of the axial tubules--axial junctions. The axial junctions averaged 510 nm in length, but they occasionally spanned an entire sarcomere. Numerical analysis showed that they contain as much as 19% of a cell's RyRs. Tomographic analysis confirmed the axial junction's architecture, which is indistinguishable from junctions on transverse tubules or on the surface, and revealed a complexly structured tubule whose lumen was only 26 nm at its narrowest point. RyRs on axial junctions colocalize with Ca(v)1.2, suggesting that they play a role in excitation-contraction coupling.
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Registered trials
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