ArticleBiophysical journal2009
An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Identification and Analysis of Biomarkers Associated With Lipid Metabolism and Ferroptosis in Ulcerative Colitis.Journal of immunology research · 2026Article
- Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation.Frontiers in immunology · 2025Review
- Modeling enzyme competition in eicosanoid metabolism in macrophage cells using a cybernetic framework.Journal of lipid research · 2024Article
- An adaptableMolecular omics · 2024Article
- Metabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Modeling transcriptional regulation of the cell cycle using a novel cybernetic-inspired approach.Biophysical journal · 2024Article
- S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons.Cell chemical biology · 2023Article
- 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection.PLoS pathogens · 2019Article
- Hypoxia Induces MacrophageFrontiers in immunology · 2019Article
- LOX inhibitor HOEC interfered arachidonic acid metabolic flux in collagen-induced arthritis rats.American journal of translational research · 2018Article
- Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid.Scientific reports · 2017Article
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.Nature chemical biology · 2017Article
- Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease.The Journal of biological chemistry · 2016Review
- Computational Modeling of Competitive Metabolism between ω3- and ω6-Polyunsaturated Fatty Acids in Inflammatory Macrophages.The journal of physical chemistry. B · 2016Article
- Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids.Biochimica et biophysica acta · 2015Review
- Strategies for individual phenotyping of linoleic and arachidonic acid metabolism using an oral glucose tolerance test.PloS one · 2015Article
- How informative is your kinetic model?: using resampling methods for model invalidation.BMC systems biology · 2014Article
- Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases.Biophysical journal · 2014Article
- Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains.PloS one · 2014Article
- A lipidomic perspective on inflammatory macrophage eicosanoid signaling.Advances in biological regulation · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
There is increasing evidence for a major and critical involvement of lipids in signal transduction and cellular trafficking, and this has motivated large-scale studies on lipid pathways. The Lipid Metabolites and Pathways Strategy consortium is actively investigating lipid metabolism in mammalian cells and has made available time-course data on various lipids in response to treatment with KDO(2)-lipid A (a lipopolysaccharide analog) of macrophage RAW 264.7 cells. The lipids known as eicosanoids play an important role in inflammation. We have reconstructed an integrated network of eicosanoid metabolism and signaling based on the KEGG pathway database and the literature and have developed a kinetic model. A matrix-based approach was used to estimate the rate constants from experimental data and these were further refined using generalized constrained nonlinear optimization. The resulting model fits the experimental data well for all species, and simulated enzyme activities were similar to their literature values. The quantitative model for eicosanoid metabolism that we have developed can be used to design experimental studies utilizing genetic and pharmacological perturbations to probe fluxes in lipid pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.