ArticleBiophysical journal2009
An integrated model of electrical spiking, bursting, and calcium oscillations in GnRH neurons.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- A complete biomechanical model ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Impact of β-Amyloids Induced Disruption of CaCells · 2022Article
- A unified model for two modes of bursting in GnRH neurons.Journal of computational neuroscience · 2016Article
- Cooperation of intrinsic bursting and calcium oscillations underlying activity patterns of model pre-Bötzinger complex neurons.Journal of computational neuroscience · 2013Article
- A simple integrative electrophysiological model of bursting GnRH neurons.Journal of computational neuroscience · 2012Article
- A multiphysics model of in vitro transcription coupling enzymatic reaction and precipitation formation.Biophysical journal · 2012Article
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2 authors.
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Abstract
The plasma membrane electrical activities of neurons that secrete gonadotropin-releasing hormone (GnRH) have been studied extensively. A couple of mathematical models have been developed previously to explain different aspects of these activities. The goal of this article is to develop a single model that accounts for the previously modeled experimental results and some more recent results that have not been accounted for. The latter includes two types of membrane potential bursting mechanisms and their associated cytosolic calcium oscillations. One bursting mechanism has not been reported in experiments and is thus regarded as a model prediction. Although the model is mainly based on data collected in immortalized GnRH cell lines, it is capable of explaining some properties of GnRH neurons observed in several other preparations including mature GnRH neurons in hypothalamic slices. We present a spatial model that incorporates a detailed description of calcium dynamics in a three-dimensional cell body with the ion channels evenly distributed on the cell surface. A phenomenological reduction of the spatial model into a simplified form is also presented. The simplified model will facilitate the study of the roles of plasma membrane electrical activities in the pulsatile release of GnRH.
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