ArticleBiophysical journal2009
Coefficients for active transport and thermogenesis of Ca2+-ATPase isoforms.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Recruitment of Muscle Genes as an Effect of Brown Adipose Tissue Ablation in Cold-Acclimated Brandt's Voles (International journal of molecular sciences · 2022Article
- The energy conversion in active transport of ions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cachexia: a problem of energetic inefficiency.Journal of cachexia, sarcopenia and muscle · 2014Article
- Active transport of the Ca(2+)-pump: introduction of the temperature difference as a driving force.European biophysics journal : EBJ · 2013Article
- A little engine that could: ATP-powered electrical battery and heater inside cells.Biophysical journal · 2012Article
- Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.Nature medicine · 2012Article
- On the thermodynamic efficiency of Ca²⁺-ATPase molecular machines.Biophysical journal · 2012Article
- Kinetic and mesoscopic non-equilibrium description of the Ca(2+) pump: a comparison.European biophysics journal : EBJ · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coefficients for active transport of ions and heat in vesicles with Ca(2+)-ATPase from sarcoplasmic reticulum are defined in terms of a newly proposed thermodynamic theory and calculated using experiments reported in the literature. The coefficients characterize in a quantitative manner different performances of the enzyme isoforms. Four enzyme isoforms are examined, namely from white and red muscle tissue, from blood platelets, and from brown adipose mitochondria. The results indicate that the isoforms have a somewhat specialized function. White muscle tissue and brown adipose tissue have the same active transport coefficient ratio, but the activity level of the enzyme in white muscle is higher than in brown adipose tissue. The thermogenesis ratio is high in both white muscle and brown adipose tissue, in agreement with a specific role in nonshivering thermogenesis. Other isoforms do not have this ability to generate heat. A calcium-dependence of the coefficients is found, which can be understood as being in accordance with the role of this ion as a messenger in muscle contraction as well as in thermogenesis. The investigation points to new experiments related to structure as well as to function of the isoforms.
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