ArticleBMC neuroscience2009
Symbiotic relationship between brain structure and dynamics.
Article in BMC neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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Who cites it
97 citing papers in PubMed, 212 citations in OpenAlex.
- Coupling of functional connectivity and regional cerebral blood flow reveals a physiological basis for network hubs of the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Dissociable impacts of perceived race and ascribed status in event-related brain potentials and multivariate network activity.Cognitive, affective & behavioral neuroscience · 2026Article
- A Neural Model for V1 That Incorporates Dendritic Nonlinearities and Backpropagating Action Potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Disruption of functional and structural topological organization in specific subnetwork among patients with classical trigeminal neuralgia: a graph theory-based magnetic resonance imaging study.Brain imaging and behavior · 2025Article
- Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP.PLoS computational biology · 2025Article
- BDNF-TrkB Signaling Pathway in Spinal Cord Injury: Insights and Implications.Molecular neurobiology · 2025Review
- Graph theoretical brain connectivity measures to investigate neural correlates of music rhythms associated with fear and anger.Cognitive neurodynamics · 2024Article
- Bayesian inference of frequency-specific functional connectivity in MEG imaging using a spectral graph model.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Retinal waves in adaptive rewiring networks orchestrate convergence and divergence in the visual system.Network neuroscience (Cambridge, Mass.) · 2024Article
- Adaptive rewiring: a general principle for neural network development.Frontiers in network physiology · 2024Review
- Bayesian inference of a spectral graph model for brain oscillations.NeuroImage · 2023Article
- Functional and spatial rewiring principles jointly regulate context-sensitive computation.PLoS computational biology · 2023Article
- Cortical structural and functional coupling during development and implications for attention deficit hyperactivity disorder.Translational psychiatry · 2023Article
- Complex spatiotemporal oscillations emerge from transverse instabilities in large-scale brain networks.PLoS computational biology · 2023Article
- Bayesian Inference of a Spectral Graph Model for Brain Oscillations.bioRxiv : the preprint server for biology · 2023Article
- Optimizing network neuroscience computation of individual differences in human spontaneous brain activity for test-retest reliability.Network neuroscience (Cambridge, Mass.) · 2023Article
- Stability and dynamics of a spectral graph model of brain oscillations.Network neuroscience (Cambridge, Mass.) · 2023Article
- Structural connectivity of autonomic, pain, limbic, and sensory brainstem nuclei in living humans based on 7 Tesla and 3 Tesla MRI.Human brain mapping · 2022Article
- Spectral graph theory of brain oscillations--Revisited and improved.NeuroImage · 2022Article
- Adaptive rewiring in nonuniform coupled oscillators.Network neuroscience (Cambridge, Mass.) · 2022Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain structure and dynamics are interdependent through processes such as activity-dependent neuroplasticity. In this study, we aim to theoretically examine this interdependence in a model of spontaneous cortical activity. To this end, we simulate spontaneous brain dynamics on structural connectivity networks, using coupled nonlinear maps. On slow time scales structural connectivity is gradually adjusted towards the resulting functional patterns via an unsupervised, activity-dependent rewiring rule. The present model has been previously shown to generate cortical-like, modular small-world structural topology from initially random connectivity. We provide further biophysical justification for this model and quantitatively characterize the relationship between structure, function and dynamics that accompanies the ensuing self-organization.
resultsWe show that coupled chaotic dynamics generate ordered and modular functional patterns, even on a random underlying structural connectivity. Consequently, structural connectivity becomes more modular as it rewires towards these functional patterns. Functional networks reflect the underlying structural networks on slow time scales, but significantly less so on faster time scales. In spite of ordered functional topology, structural networks remain robustly interconnected--and therefore small-world--due to the presence of central, inter-modular hub nodes. The noisy dynamics of these hubs enable them to persist despite ongoing rewiring and despite their comparative absence in functional networks.
conclusionOur results outline a theoretical mechanism by which brain dynamics may facilitate neuroanatomical self-organization. We find time scale dependent differences between structural and functional networks. These differences are likely to arise from the distinct dynamics of central structural nodes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.