Evidence map›Paper›PMID 19486530›Full record

SynthesisBMC psychiatry2009

Epidemiologic heterogeneity of common mood and anxiety disorders over the lifecourse in the general population: a systematic review.

Arijit Nandi, John R Beard, Sandro Galea

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  7. Efficacy and safety of zuranolone co-initiated with an antidepressant in adults with major depressive disorder: results from the phase 3 CORAL study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Arijit NandiCenter for Urban Epidemiologic Studies, New York Academy of Medicine, New York, USA. anandi@hsph.harvard.edu
John R Beard
Sandro Galea

Funding

National Center for Disaster Mental Health ResearchP60MH082598 · NIMH · DARTMOUTH COLLEGE · PI NORRIS, FRAN H · 2007 to 2011
$4.7M
Ecologic Stressors, PTSD, and Drug Use in DetroitR01DA022720 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AIELLO, ALLISON E · 2007 to 2011
$4.7M
The neighborhood environment and drug use in NYCR01DA017642 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GALEA, SANDRO · 2004 to 2007
$2.0M
Ecological Approaches to Understanding Post-Disaster DistressR01MH078152 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GALEA, SANDRO · 2006 to 2008
$1.5M
NIDA NIH HHS DA017642NIDA NIH HHS DA022720NIDA NIH HHS R01 DA017642NIDA NIH HHS R01 DA022720NIMH NIH HHS MH078152NIMH NIH HHS MH082598NIMH NIH HHS P60 MH082598NIMH NIH HHS R01 MH078152
6 · The paper itself

Abstract

backgroundClinical evidence has long suggested there may be heterogeneity in the patterns and predictors of common mood and anxiety disorders; however, epidemiologic studies have generally treated these outcomes as homogenous entities. The objective of this study was to systematically review the epidemiologic evidence for potential patterns of heterogeneity of common mood and anxiety disorders over the lifecourse in the general population.

methodsWe reviewed epidemiologic studies examining heterogeneity in either the nature of symptoms experienced ("symptom syndromes") or in patterns of symptoms over time ("symptom trajectories"). To be included, studies of syndromes were required to identify distinct symptom subtypes, and studies of trajectories were required to identify distinct longitudinal patterns of symptoms in at least three waves of follow-up. Studies based on clinical or patient populations were excluded.

resultsWhile research in this field is in its infancy, we found growing evidence that, not only can mood and anxiety disorders be differentiated by symptom syndromes and trajectories, but that the factors associated with these disorders may vary between these subtypes. Whether this reflects a causal pathway, where genetic or environmental factors influence the nature of the symptom or trajectory subtype experienced by an individual, or whether individuals with different subtypes differed in their susceptibility to different environmental factors, could not be determined. Few studies addressed issues of comorbidity or transitions in symptoms between common disorders.

conclusionUnderstanding the diversity of these conditions may help us identify preventable factors that are only associated with some subtypes of these common disorders.

Indexed as

AdultAgedAge FactorsAnxiety DisordersData CollectionDepressive DisorderFemaleHumansLife Change EventsLongitudinal StudiesMiddle AgedMood DisordersPsychiatric Status Rating ScalesRisk FactorsSocial EnvironmentSyndrome

Identifiers

PMID19486530
PMCPMC2700109

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.