Evidence map›Paper›PMID 19486506›Full record

ReviewJournal of biology2009

Notch signaling, the segmentation clock, and the patterning of vertebrate somites.

Julian Lewis, Anja Hanisch, Maxine Holder

Abstract readReview
In one paragraph

Review in Journal of biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Loss of U11/U12 spliceosome geneLife science alliance · 2026
    Article
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  7. VRTN is Required for the Development of Thoracic Vertebrae in Mammals.International journal of biological sciences · 2018
    Article
  8. Article
  9. Delta-Notch signalling in segmentation.Arthropod structure & development · 2017
    Review
  10. Article
  11. Article
  12. Article
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  19. Dynamic properties of the segmentation clock mediated by microRNA.International journal of clinical and experimental pathology · 2015
    Article
  20. Stochastic simulation of notch signaling reveals novel factors that mediate the differentiation of neural stem cells.Journal of computational biology : a journal of computational molecular cell biology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Julian LewisVertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. julian.lewis@cancer.org.uk
Anja Hanisch
Maxine Holder

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Notch signaling pathway has multifarious functions in the organization of the developing vertebrate embryo. One of its most fundamental roles is in the emergence of the regular pattern of somites that will give rise to the musculoskeletal structures of the trunk. The parts it plays in the early operation of the segmentation clock and the later definition and differentiation of the somites are beginning to be understood.

Indexed as

Signal TransductionAnimalsBiological ClocksGene Expression RegulationReceptors, NotchSomitesVertebratesReceptors, Notch

Identifiers

PMID19486506
PMCPMC2688916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.