ArticleMolecular microbiology2009
Cognate Site Identifier analysis reveals novel binding properties of the Sex Inducer homeodomain proteins of Cryptococcus neoformans.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Dissecting the homeodomainmBio · 2026Article
- Dissecting the homeodomainbioRxiv : the preprint server for biology · 2025Article
- Ontogenetic Variation in Macrocyclic and Hemicyclic Poplar Rust Fungi.International journal of molecular sciences · 2022Article
- High-Density RNA Microarrays Synthesized In Situ by Photolithography.Angewandte Chemie (International ed. in English) · 2018Article
- Genetic Dissection of Sexual Reproduction in a Primary Homothallic Basidiomycete.PLoS genetics · 2016Article
- Targets of the Sex Inducer homeodomain proteins are required for fungal development and virulence in Cryptococcus neoformans.Molecular microbiology · 2015Article
- Genomic mining of prokaryotic repressors for orthogonal logic gates.Nature chemical biology · 2014Article
- Profiling a killer, the development of Cryptococcus neoformans.FEMS microbiology reviews · 2012Review
- Establishing an unusual cell type: how to make a dikaryon.Current opinion in microbiology · 2010Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Homeodomain proteins function in fungi to specify cell types and control sexual development. In the meningoencephalitis-causing fungal pathogen Cryptococcus neoformans, sexual development leads to the production of spores (suspected infectious particles). Sexual development is controlled by the homeodomain transcription factors Sxi1alpha and Sxi2a, but the mechanism by which they act is unknown. To understand how the Sxi proteins regulate development, we characterized their binding properties in vitro, showing that Sxi2a does not require a partner to bind DNA with high affinity. We then utilized a novel approach, Cognate Site Identifier (CSI) arrays, to define a comprehensive DNA-binding profile for Sxi2a, revealing a consensus sequence distinct from those of other fungal homeodomain proteins. Finally, we show that the homeodomains of both Sxi proteins are required for sexual development, a departure from related fungi. Our findings support a model in which Sxi1alpha and Sxi2a control sexual development in a homeodomain-dependent manner by binding to DNA sequences that differ from those defined in previously established fungal paradigms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.