ArticleBehavioral neuroscience2009
Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults.
Article in Behavioral neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 180 citations in OpenAlex.
- Structural remodeling of medium spiny neurons in the tail of the striatum and stress-related behavioral alterations after early handling and adolescent stress in male rats.IBRO neuroscience reports · 2026Article
- Central amygdalaNeurobiology of stress · 2026Article
- Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype.Neurobiology of stress · 2024Article
- Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype.bioRxiv : the preprint server for biology · 2024Article
- Prenatal infection and adolescent social adversity affect microglia, synaptic density, and behavior in male rats.Neurobiology of stress · 2023Article
- Effects of a True Prophylactic Treatment on Hippocampal and Amygdala Synaptic Plasticity and Gene Expression in a Rodent Chronic Stress Model of Social Defeat.International journal of molecular sciences · 2023Article
- Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience.International journal of molecular sciences · 2022Review
- Neurobiological Bases of Alcohol Consumption After Social Stress.Current topics in behavioral neurosciences · 2022Article
- Adolescent stress during, but not after, pubertal onset impairs indices of prepulse inhibition in adult rats.Developmental psychobiology · 2021Article
- Understanding stress: Insights from rodent models.Current research in neurobiology · 2021Review
- Sex-Specific Retinal Anomalies Induced by Chronic Social Defeat Stress in Mice.Frontiers in behavioral neuroscience · 2021Article
- Anti-Stress Properties of Atypical Antipsychotics.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice.Neuroscience bulletin · 2020Article
- Can I Get a Witness? Using Vicarious Defeat Stress to Study Mood-Related Illnesses in Traditionally Understudied Populations.Biological psychiatry · 2020Review
- The Long-Term Effects of Adolescent Social Defeat Stress on Oligodendrocyte Lineage Cells and Neuroinflammatory Mediators in Mice.Neuropsychiatric disease and treatment · 2020Article
- Sensorimotor developmental factors influencing the performance of laboratory rodents on learning and memory.Behavioural brain research · 2019Review
- Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats.Scientific reports · 2019Article
- Preliminary data indicating a connection between stress-induced prefrontal dopamine release and hippocampal TSPO expression in the psychosis spectrum.Schizophrenia research · 2019Article
- Pharmacological modulation of the behavioral effects of social defeat in memory and learning in male mice.Psychopharmacology · 2019Article
- Serotonin Signaling Trough Prelimbic 5-HT1A Receptors Modulates CSDS-Induced Behavioral Changes in Adult Female Voles.The international journal of neuropsychopharmacology · 2019Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Social stress in adolescence is correlated with emergence of psychopathologies during early adulthood. In this study, the authors investigated the impact of social defeat stress during mid-adolescence on adult male brain and behavior. Adolescent male Sprague-Dawley rats were exposed to repeated social defeat for 5 days while controls were placed in a novel empty cage. When exposed to defeat-associated cues as adults, previously defeated rats showed increased risk assessment and behavioral inhibition, demonstrating long-term memory for the defeat context. However, previously defeated rats exhibited increased locomotion in both elevated plus-maze and open field tests, suggesting heightened novelty-induced behavior. Adolescent defeat also affected adult monoamine levels in stress-responsive limbic regions, causing decreased medial prefrontal cortex dopamine, increased norepinephrine and serotonin in the ventral dentate gyrus, and decreased norepinephrine in the dorsal raphe. Our results suggest that adolescent social defeat produces both deficits in anxiety responses and altered monoaminergic function in adulthood. This model offers potential for identifying specific mechanisms induced by severe adolescent social stress that may contribute to increased adult male vulnerability to psychopathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.