GuidelineActa paediatrica (Oslo, Norway : 1992)2009
Guidelines for procedural pain in the newborn.
Guideline in Acta paediatrica (Oslo, Norway : 1992), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 60 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maternal Involvement in Pain Management in NICU: a Randomized Controlled Trial
Effects of Neonatal Therapeutic Touch and Massage in Very Preterm and Extremely Preterm Neonates: A Randomized Controlled Trial
Who cites it
60 citing papers in PubMed, 6 syntheses or guidelines pooled it, 256 citations in OpenAlex.
- Sucrose analgesia for venepuncture in neonates.The Cochrane database of systematic reviews · 2026Pooled it
- The comparative efficacy and safety of sweet solutions to reduce preterm infants' pain levels: a systematic review and network meta-analysis.Systematic reviews · 2026Pooled it
- Pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated neonates.The Cochrane database of systematic reviews · 2025Pooled it
- Capillary blood sampling: national recommendations on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine.Biochemia medica · 2015Guideline
- [Non-pharmaceutical measures, topical analgesics and oral administration of glucose in pain management: Austrian interdisciplinary recommendations on pediatric perioperative pain management].Schmerz (Berlin, Germany) · 2014Guideline
- A systematic review and meta-analyses of nonsucrose sweet solutions for pain relief in neonates.Pain research & managementPooled it
- Trial
- Neonatal pain response to automatic lancet versus needle heel-prick blood sampling: A prospective randomized controlled clinical trial.Pediatrics international : official journal of the Japan Pediatric Society · 2020Trial
- Oral sweet solution to prevent pain during neonatal hip examination: a randomised controlled trial.Acta paediatrica (Oslo, Norway : 1992) · 2019Trial
- [Clinical effect of maternal voice stimulation in alleviating procedural pain in hospitalized neonates].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Trial
- Oxidative Stress as a Physiological Pain Response in Full-Term Newborns.Oxidative medicine and cellular longevity · 2017Trial
- Trial
- The effect of the facilitated tucking position in reducing vaccination-induced pain in newborns.Italian journal of pediatrics · 2015Trial
- The effects of massage therapy to induce sleep in infants born preterm.Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association · 2014Trial
- Effects of daily kangaroo care on cardiorespiratory parameters in preterm infants.Journal of neonatal-perinatal medicine · 2013Trial
- Propofol versus midazolam for intubating preterm neonates: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2011Trial
- Management of umbilical venous and arterial catheter: Neonatal European Vascular Access Team- ESPR Recommendation 2.Pediatric research · 2026Article
- Neonatal vascular access: management of pain and distress during vascular access device placement.Pediatric research · 2026Article
- Insertion and management of intraosseous devices: Neonatal European Vascular Access Team - ESPR Recommendation 9.Pediatric research · 2026Article
- Exit site management: neonatal european vascular access team - ESPR recommendation 7.Pediatric research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledDespite accumulating evidence that procedural pain experienced by newborn infants may have acute and even long-term detrimental effects on their subsequent behaviour and neurological outcome, pain control and prevention remain controversial issues. Our aim was to develop guidelines based on evidence and clinical practice for preventing and controlling neonatal procedural pain in the light of the evidence-based recommendations contained in the SIGN classification. A panel of expert neonatologists used systematic review, data synthesis and open discussion to reach a consensus on the level of evidence supported by the literature or customs in clinical practice and to describe a global analgesic management, considering pharmacological, non-pharmacological, behavioural and environmental measures for each invasive procedure. There is strong evidence to support some analgesic measures, e.g. sucrose or breast milk for minor invasive procedures, and combinations of drugs for tracheal intubation. Many other pain control measures used during chest tube placement and removal, screening and treatment for ROP, or for postoperative pain, are still based not on evidence, but on good practice or expert opinions.
conclusionThese guidelines should help improving the health care professional's awareness of the need to adequately manage procedural pain in neonates, based on the strongest evidence currently available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.