ArticleNeoplasia (New York, N.Y.)2009
Optical molecular imaging of epidermal growth factor receptor expression to improve detection of oral neoplasia.
Article in Neoplasia (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- In vivo photoacoustic tomography of EGFR overexpressed in hepatocellular carcinoma mouse xenograft.Photoacoustics · 2016Article
- Widefield optical imaging of changes in uptake of glucose and tissue extracellular pH in head and neck cancer.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- A comparative study of affibody, panitumumab, and EGF for near-infrared fluorescence imaging of EGFR- and EGFRvIII-expressing tumors.Cancer biology & therapy · 2014Article
- Optical molecular imaging detects changes in extracellular pH with the development of head and neck cancer.International journal of cancer · 2013Article
- Microscopic Delineation of Medulloblastoma Margins in a Transgenic Mouse Model Using a Topically Applied VEGFR-1 Probe.Translational oncology · 2012Article
- Optical molecular imaging of multiple biomarkers of epithelial neoplasia: epidermal growth factor receptor expression and metabolic activity in oral mucosa.Translational oncology · 2012Article
- Advances in molecular imaging: targeted optical contrast agents for cancer diagnostics.Nanomedicine (London, England) · 2012Review
- Rapid Stereomicroscopic Imaging of HER2 Overexpression in Ex Vivo Breast Tissue Using Topically Applied Silica-Based Gold Nanoshells.Journal of oncology · 2012Article
- Near infrared imaging of EGFR of oral squamous cell carcinoma in mice administered arsenic trioxide.PloS one · 2012Article
- The interconnectedness of cancer cell signaling.Neoplasia (New York, N.Y.) · 2011Article
- Rational chemical design of the next generation of molecular imaging probes based on physics and biology: mixing modalities, colors and signals.Chemical Society reviews · 2011Review
- Dinosaurs and ancient civilizations: reflections on the treatment of cancer.Neoplasia (New York, N.Y.) · 2010Article
- Combined magnetic resonance and optical imaging of head and neck tumor xenografts using Gadolinium-labelled phosphorescent polymeric nanomicelles.Head & neck oncology · 2010Article
- Optical diagnostics in the oral cavity: an overview.Oral diseases · 2010Review
- In vivo imaging of xenograft tumors using an epidermal growth factor receptor-specific affibody molecule labeled with a near-infrared fluorophore.Neoplasia (New York, N.Y.) · 2010Article
- Targeted drug delivery in pancreatic cancer.Biochimica et biophysica acta · 2010Review
- The War on Cancer rages on.Neoplasia (New York, N.Y.) · 2009Article
- Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells.Neoplasia (New York, N.Y.) · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe development of noninvasive molecular imaging approaches has the potential to improve management of cancer.
methodsIn this study, we demonstrate the potential of noninvasive topical delivery of an epidermal growth factor-Alexa 647 (EGF-Alexa 647) conjugate to image changes in epidermal growth factor receptor expression associated with oral neoplasia. We report a series of preclinical analyses to evaluate the optical contrast achieved after topical delivery of EGF-Alexa 647 in a variety of model systems, including cells, three-dimensional tissue cultures, and intact human tissue specimens using wide-field and high-resolution fluorescence imaging. Data were collected from 17 different oral cancer patients: eight pairs of normal and abnormal biopsies and nine resected tumors were examined.
resultsThe EGF-dye conjugate can be uniformly delivered throughout the oral epithelium with a penetration depth exceeding 500 microm and incubation time of less than 30 minutes. After EGF-Alexa 647 incubation, the presence of oral neoplasia is associated with a 1.5- to 6.9-fold increase in fluorescence contrast compared with grossly normal mucosa from the same patient with both wide-field and high-resolution fluorescence imaging.
conclusionsResults illustrate the potential of EGF-targeted fluorescent agents for in vivo molecular imaging, a technique that may aid in the diagnosis and characterization of oral neoplasia and allow real-time detection of tumor margins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.