ArticleHealth services & outcomes research methodology2008
Causal Mediation Analyses for Randomized Trials.
Article in Health services & outcomes research methodology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04214327 (Strengthening Families Program Online for Teens and Families), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strengthening Families Program Online for Teens and Families
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An individual participant data meta-analysis investigating the mediating role of eating behavior traits in Acceptance and Commitment Therapy-based weight management interventions.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Pooled it
- Effectiveness of problem gambling interventions in a service setting: a protocol for a pragmatic randomised controlled clinical trial.BMJ open · 2017Trial
- FAST INdiCATE Trial protocol. Clinical efficacy of functional strength training for upper limb motor recovery early after stroke: neural correlates and prognostic indicators.International journal of stroke : official journal of the International Stroke Society · 2014Trial
- Causal Inference in Studies with Functional Unmasking: Psychedelics and Beyond.medRxiv : the preprint server for health sciences · 2026Article
- Estimating bias from withdrawal of life sustaining treatment in clinical trials.Critical care (London, England) · 2025Review
- From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.American journal of respiratory and critical care medicine · 2024Review
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- Design and methods of a randomized web-based physical activity intervention among children with cancer: A report from the Children's Oncology Group.Contemporary clinical trials · 2022Article
- Adjuvant Systemic Therapies for Patients with Renal Cell Carcinoma: Choosing Treatment Based on Patient-level Characteristics.European urology oncology · 2022Article
- The West Philadelphia asthma care implementation study (NHLBI#Contemporary clinical trials communications · 2021Article
- Preventing sexual violence in college men: a randomized-controlled trial of GlobalConsent.BMC public health · 2020Article
- High-dimensional mediation analysis in survival models.PLoS computational biology · 2020Article
- Causal Mediation Analysis in the Presence of Post-treatment Confounding Variables: A Monte Carlo Simulation Study.Frontiers in psychology · 2020Article
- Mediators of a 12-month change in physical activity in ethnically diverse sample of postpartum women.Translational journal of the American College of Sports Medicine · 2019Article
- Risk-benefit profile of intensive blood pressure treatment - Authors' reply.The lancet. Diabetes & endocrinology · 2018Article
- Article
- Identification and Estimation of Causal Mechanisms in Clustered Encouragement Designs: Disentangling Bed Nets using Bayesian Principal Stratification.Journal of the American Statistical Association · 2016Article
- Statistical approaches for enhancing causal interpretation of the M to Y relation in mediation analysis.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2015Article
- Prevention system mediation of communities that care effects on youth outcomes.Prevention science : the official journal of the Society for Prevention Research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In the context of randomized intervention trials, we describe causal methods for analyzing how post-randomization factors constitute the process through which randomized baseline interventions act on outcomes. Traditionally, such mediation analyses have been undertaken with great caution, because they assume that the mediating factor is also randomly assigned to individuals in addition to the randomized baseline intervention (i.e., sequential ignorability). Because the mediating factors are typically not randomized, such analyses are unprotected from unmeasured confounders that may lead to biased inference. We review several causal approaches that attempt to reduce such bias without assuming that the mediating factor is randomized. However, these causal approaches require certain interaction assumptions that may be assessed if there is enough treatment heterogeneity with respect to the mediator. We describe available estimation procedures in the context of several examples from the literature and provide resources for software code.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.