ArticleNature2009
Genome-wide silencing in Drosophila captures conserved apoptotic effectors.
Article in Nature, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Apoptosis-resistant cells drive compensatory proliferation via cell-autonomous and non-autonomous functions of the initiator caspase Dronc.Nature communications · 2025Article
- miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer's model.Cell death & disease · 2024Article
- Dissecting morphogenetic apoptosis through a genetic screen in Drosophila.Life science alliance · 2023Article
- Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters.G3 (Bethesda, Md.) · 2021Article
- A Genetic Screen inG3 (Bethesda, Md.) · 2020Article
- RNA Interference (RNAi) Screening inGenetics · 2018Article
- Tango7 regulates cortical activity of caspases during reaper-triggered changes in tissue elasticity.Nature communications · 2017Article
- Caspase-dependent non-apoptotic processes in development.Cell death and differentiation · 2017Review
- Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease.Cell death and differentiation · 2017Review
- Article
- The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila.Cell death and differentiation · 2016Article
- A systems-level interrogation identifies regulators of Drosophila blood cell number and survival.PLoS genetics · 2015Article
- Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities.British journal of pharmacology · 2014Review
- The E3 ubiquitin ligase XIAP restricts Anaplasma phagocytophilum colonization of Ixodes scapularis ticks.The Journal of infectious diseases · 2013Article
- Mitochondrial regulation of cell death.Cold Spring Harbor perspectives in biology · 2013Review
- Tango7 directs cellular remodeling by the Drosophila apoptosome.Genes & development · 2013Article
- The 'ubiquitous' reality of vector immunology.Cellular microbiology · 2013Review
- Transcriptional networks controlling the cell cycle.G3 (Bethesda, Md.) · 2013Article
- The dREAM/Myb-MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin.Developmental biology · 2012Article
- Effectors of alcohol-induced cell killing in Drosophila.Cell death and differentiation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Apoptosis is a conserved form of programmed cell death firmly established in the aetiology, pathogenesis and treatment of many human diseases. Central to the core machinery of apoptosis are the caspases and their proximal regulators. Current models for caspase control involve a balance of opposing elements, with variable contributions from positive and negative regulators among different cell types and species. To advance a comprehensive view of components that support caspase-dependent cell death, we conducted a genome-wide silencing screen in the Drosophila model. Our strategy used a library of double-stranded RNAs together with a chemical antagonist of Inhibitor of apoptosis proteins (IAPs) that simulates the action of native regulators in the Reaper and Smac (also known as Diablo) families. Here we present a highly validated set of targets that is necessary for death provoked by several stimuli. Among these, Tango7 is identified as a new effector. Cells depleted for this gene resisted apoptosis at a step before the induction of effector caspase activity, and the directed silencing of Tango7 in Drosophila prevented caspase-dependent programmed cell death. Unlike known apoptosis regulators in this model system, Tango7 activity did not influence stimulus-dependent loss of Drosophila DIAP1 (also known as th and IAP1), but instead regulated levels of the apical caspase Dronc (Nc). Similarly, the human Tango7 counterpart, PCID1 (also known as EIF3M), impinged on caspase 9, revealing a new regulatory axis affecting the apoptosome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.