ArticleNucleic acids research2009
Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma.World journal of gastrointestinal oncology · 2024Article
- LINC02381 suppresses cell proliferation and promotes apoptosis via attenuating IGF1R/PI3K/AKT signaling pathway in breast cancer.Functional & integrative genomics · 2023Article
- Emerging Roles of Long Non-coding RNAs in Uterine Leiomyoma Pathogenesis: a Review.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Identification of genetic risk loci for depression and migraine comorbidity in Han Chinese residing in Taiwan.Frontiers in psychiatry · 2022Article
- Article
- Precision treatment exploration of breast cancer based on heterogeneity analysis of lncRNAs at the single-cell level.BMC cancer · 2021Article
- Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells.International journal of molecular medicine · 2020Article
- Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance.Oncogene · 2020Review
- [Long noncoding RNA UFC1 promotes metastasis and invasion of hepatocellular carcinoma cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Article
- New Insights into the Implication of Epigenetic Alterations in the EMT of Triple Negative Breast Cancer.Cancers · 2019Review
- Review
- LncRNA SRA1 may play a role in the uterine leiomyoma tumor growth regarding theInternational journal of women's health · 2019Article
- Deciphering the roles of lncRNAs in breast development and disease.Oncotarget · 2018Review
- New Insights Into the Long Non-coding RNA SRA: Physiological Functions and Mechanisms of Action.Frontiers in medicine · 2018Review
- Long non-coding RNA, steroid receptor RNA activator (SRA), induces tumor proliferation and invasion through the NOTCH pathway in cervical cancer cell lines.Oncology reports · 2017Article
- NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Short intron-derived ncRNAs.Nucleic acids research · 2017Article
- LncRNA16 is a potential biomarker for diagnosis of early-stage lung cancer that promotes cell proliferation by regulating the cell cycle.Oncotarget · 2017Article
- Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication.Oncotarget · 2017Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Products of the Steroid Receptor RNA Activator gene (SRA1) have the unusual property to modulate the activity of steroid receptors and other transcription factors both at the RNA (SRA) and the protein (SRAP) level. Balance between these two genetically linked entities is controlled by alternative splicing of intron-1, whose retention alters SRAP reading frame. We have previously found that both fully-spliced SRAP-coding and intron-1-containing non-coding SRA RNAs co-exist in breast cancer cell lines. Herein, we report a significant (Student's t-test, P < 0.003) higher SRA-intron-1 relative expression in breast tumors with higher progesterone receptor contents. Using an antisense oligoribonucleotide, we have successfully reprogrammed endogenous SRA splicing and increased SRA RNA-intron-1 relative level in T5 breast cancer cells. This increase is paralleled by significant changes in the expression of genes such as plasminogen urokinase activator and estrogen receptor beta. Estrogen regulation of other genes, including the anti-metastatic NME1 gene, is also altered. Overall, our results suggest that the balance coding/non-coding SRA transcripts not only characterizes particular tumor phenotypes but might also, through regulating the expression of specific genes, be involved in breast tumorigenesis and tumor progression.
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