ReviewFrontiers in bioscience (Landmark edition)2009
Settings and mechanisms for trans-cellular diapedesis.
Review in Frontiers in bioscience (Landmark edition), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Endothelial transmigration by Trypanosoma cruzi.PloS one · 2013Trial
- TNF-α induces VE-cadherin-dependent gap/JAIL cycling through an intermediate state essential for neutrophil transmigration.Frontiers in immunology · 2025Article
- Neutrophil Extracellular DNA Traps in Response to Infection or Inflammation, and the Roles of Platelet Interactions.International journal of molecular sciences · 2024Review
- Blood-brain barrier dysfunction in intensive care unit.Journal of intensive medicine · 2023Review
- Article
- Targeting Chemokine-Glycosaminoglycan Interactions to Inhibit Inflammation.Frontiers in immunology · 2020Review
- Review
- Endothelial cell-cell adhesion and signaling.Experimental cell research · 2017Review
- ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment: A new step in migration.Hepatology (Baltimore, Md.) · 2017Article
- Transendothelial migration: unifying principles from the endothelial perspective.Immunological reviews · 2016Review
- Tumor cell intravasation.American journal of physiology. Cell physiology · 2016Review
- Mechanism of Diapedesis: Importance of the Transcellular Route.Advances in immunology · 2016Review
- The regulation of transendothelial migration: new knowledge and new questions.Cardiovascular research · 2015Review
- T Lymphocyte-Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity.Frontiers in immunology · 2015Review
- Endothelial monolayers and transendothelial migration depend on mechanical properties of the substrate.Cytoskeleton (Hoboken, N.J.) · 2014Article
- Probing the biomechanical contribution of the endothelium to lymphocyte migration: diapedesis by the path of least resistance.Journal of cell science · 2014Article
- The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.The Journal of experimental medicine · 2014Article
- Neutrophil and monocyte recruitment by PECAM, CD99, and other molecules via the LBRC.Seminars in immunopathology · 2014Review
- Reactive oxygen species in inflammation and tissue injury.Antioxidants & redox signaling · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Immune system functions require blood leukocytes to continuously traffic throughout the body and repeatedly cross endothelial barriers (i.e., diapedese) as they enter (intravasation) and exit (extravasation) the circulation. The earliest studies to directly characterize diapedesis in vivo suggested co-existence of two distinct migratory pathways: between (para-cellular) and through (trans-cellular) individual endothelial cells. However, in the absence of conclusive in vitro observations, the latter pathway remained poorly accepted. The recent emergence of unambiguous in vitro reports of trans-cellular diapedesis has begun to illuminate mechanisms for this pathway and has renewed interest in its physiological roles. A thorough reevaluation of the existing literature reveals a large number of studies documenting significant use of the trans-cellular pathway in diverse in vivo settings. These include constitutive trafficking in bone marrow and lymphoid organs as well as upregulated extravasation in peripheral tissues during inflammation. Here we collectively summarize these in vivo observations alongside the emerging in vitro data in order to provide a framework for understanding the settings, mechanisms and roles for the trans-cellular route of diapedesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.