ArticleClinical immunology (Orlando, Fla.)2009
Changes in autoreactive T cell avidity during type 1 diabetes development.
Article in Clinical immunology (Orlando, Fla.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.Journal of immunology (Baltimore, Md. : 1950) · 2011Trial
- Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity.PLoS biology · 2024Article
- Antigen-specific T cell responses in autoimmune diabetes.Frontiers in immunology · 2024Review
- A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery.Diabetes · 2020Article
- Increased Effector Memory Insulin-Specific CD4Diabetes · 2017Article
- Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes.Frontiers in physiology · 2016Article
- Continuum model of T-cell avidity: Understanding autoreactive and regulatory T-cell responses in type 1 diabetes.Journal of theoretical biology · 2015Article
- Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes.Journal of theoretical biology · 2015Article
- TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Mechanistic basis of immunotherapies for type 1 diabetes mellitus.Translational research : the journal of laboratory and clinical medicine · 2013Review
- Mapping I-A(g7) restricted epitopes in murine G6PC2.Immunologic research · 2013Article
- Frequency of epitope-specific naive CD4(+) T cells correlates with immunodominance in the human memory repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Viruses and cytotoxic T lymphocytes in type 1 diabetes.Clinical reviews in allergy & immunology · 2011Review
- Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction.PloS one · 2011Article
- Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes.Human vaccines · 2011Review
- T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives.Clinical & developmental immunology · 2011Review
- Prediction and pathogenesis in type 1 diabetes.Immunity · 2010Review
- Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.Journal of virology · 2010Article
- On-chip activation and subsequent detection of individual antigen-specific T cells.Analytical chemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The activation threshold for antigen-specific T cell responses is dependent on the avidity of the trimolecular interaction between TCR, antigen, and MHC. We compared CD4+ T cell avidities for the diabetes-associated autoantigen glutamic acid decarboxylase 555-567 (GAD 555) among serial samples from autoantibody-positive subjects at high risk of progression to type 1 diabetes (T1D). T cells from three at-risk subjects demonstrated significant avidity increases (p<0.05 by F test) over time. This avidity shift correlated with the outgrowth of T cells expressing TCR BV 9, 15, 17 or 20 that demonstrated higher GAD 555 tetramer-binding levels compared to cells expressing other TCR BV genes. Similar analysis of autoantibody-negative, first-degree relatives and T1D patients did not demonstrate similar changes in avidity. These data implicate the outgrowth of T cells expressing higher affinity TCR in a process of antigen-specific T cell avidity maturation during the pre-clinical stage of T1D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.