Evidence map›Paper›PMID 19482514›Full record

ReviewTrends in molecular medicine2009

Non-invasive molecular imaging of prostate cancer lymph node metastasis.

Frédéric Pouliot, Mai Johnson, Lily Wu

Open access · greenAbstract readEvaluation StudyReview
In one paragraph

Review in Trends in molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. FDG-PET/CT for pre-operative staging and prognostic stratification of patients with high-grade prostate cancer at biopsy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2015
    Article
  9. Article
  10. Article
  11. Preclinical lymphatic imaging.Molecular imaging and biology · 2011
    Review
  12. In vivo imaging of intraprostatic-specific gene transcription by PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2011
    Article
  13. Oxidative stress and DNA methylation in prostate cancer.Obstetrics and gynecology international · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Frédéric PouliotDepartment of Urology, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
Mai Johnson
Lily Wu
University of California, Los Angeles · US

Funding

UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREEMAN, MICHAEL R · 2002 to 2023
$42.6M
TUMOR CELL SURFACES AND CHROMOSOMEST32CA009056 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gay M Crooks, David A. Nathanson · 1985 to 2026
$10.5M
Gene-Based Imaging and Therapy To Target Prostate CancerR01CA101904 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, LILY · 2003 to 2012
$2.9M
PET-guided Intervention in Lymphatic Metastasis of Prostate CancerR21CA122693 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, LILY · 2007 to 2008
$340k
NCI NIH HHS P50 CA092131NCI NIH HHS R01 CA101904NCI NIH HHS R21 CA122693NCI NIH HHS T32 CA009056
6 · The paper itself

Abstract

Imaging in medicine has been classically based on the anatomical description of organs. In the past 15 years, new imaging techniques based on gene expression that characterize a pathological process have been developed. Molecular imaging is the use of such molecules to image cell-specific characteristics. Here, we review recent advances in molecular imaging, taking as our prime example lymph node (LN) metastasis in prostate cancer. We describe the new techniques and compare their accuracy in detecting LN metastasis in prostate cancer. We also present new molecular strategies for improving tumor detection using adenoviruses, molecular promoters and amplification systems. Finally, we present the concept of 'in vivo pathology', which envisages using molecular imaging to accurately localize metastatic lesions based on the molecular signature of the disease.

Indexed as

AnimalsDiagnostic ImagingHumansLymphatic MetastasisMagnetic Resonance ImagingMalePositron-Emission TomographyProstatic NeoplasmsRadiography

Identifiers

PMID19482514
PMCPMC2798142
OpenAlexW2004937246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.