SynthesisAmerican journal of obstetrics and gynecology2009
Antenatal magnesium sulfate for the prevention of cerebral palsy in preterm infants less than 34 weeks' gestation: a systematic review and metaanalysis.
Synthesis in American journal of obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 7 syntheses or guidelines pooled it, 271 citations in OpenAlex.
- Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.The Cochrane database of systematic reviews · 2026Pooled it
- Magnesium sulfate for fetal neuroprotection in preterm pregnancy: a meta-analysis of randomized controlled trials.BMC pregnancy and childbirth · 2024Pooled it
- Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.The Cochrane database of systematic reviews · 2024Pooled it
- A Systematic Review of Magnesium Sulfate for Perinatal Neuroprotection: What Have We Learnt From the Past Decade?Frontiers in neurology · 2020Pooled it
- Prognostic factors for cerebral palsy and motor impairment in children born very preterm or very low birthweight: a systematic review.Developmental medicine and child neurology · 2016Pooled it
- Magnesium sulphate for women at term for neuroprotection of the fetus.The Cochrane database of systematic reviews · 2013Pooled it
- Different magnesium sulphate regimens for neuroprotection of the fetus for women at risk of preterm birth.The Cochrane database of systematic reviews · 2012Pooled it
- Evaluating the use of the QUiPP app and its impact on the management of threatened preterm labour: A cluster randomised trial.PLoS medicine · 2021Trial
- Randomized controlled trial of magnesium sulfate in women at risk of preterm delivery-neonatal cardiovascular effects.Journal of perinatology : official journal of the California Perinatal Association · 2012Trial
- Prenatal exposure to hypertensive disorders and adolescent brain white matter development.Pediatric research · 2026Article
- Article
- Evaluation of the Relationship Between Isometric Exercise and Roll-Over Tests and the Levels of Pregnancy-Associated Plasma Protein A and Beta-Human Chorionic Gonadotropin and Neutrophil-Lymphocyte Ratio in the Early Diagnosis of Preeclampsia.Obstetrics and gynecology international · 2026Article
- Association of individual and bundled evidence-based practices with adverse outcomes in very preterm infants: a multicenter retrospective study.Frontiers in pediatrics · 2026Article
- Prenatal Magnesium Sulfate Exposure Is Not Associated with Different Neurodevelopmental Outcomes by Sex in Extremely Preterm Infants.Brain sciences · 2025Article
- Review
- Clinical guidance VVOG: Antenatal care for twin pregnancies.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Current Approaches and Innovations in Managing Preeclampsia: Highlighting Maternal Health Disparities.Journal of clinical medicine · 2025Review
- Antenatal Low Dose Magnesium Sulphate for Foetal Neuroprotection in Preterm Birth Versus Control: A Comparative Prospective Cohort Study in Tertiary Care Centre in India.Journal of obstetrics and gynaecology of India · 2025Article
- Magnesium sulfate and risk of hypoxic-ischemic encephalopathy in a high-risk cohort.American journal of obstetrics and gynecology · 2024Article
- Clinical application of amino-terminal pro-brain natriuretic peptide concentration in amniotic fluid for the prediction of preterm birth in symptomatic women.AJOG global reports · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We conducted a systematic review and metaanalysis of randomized controlled trials to determine whether magnesium sulfate administered to women at risk of preterm delivery before 34 weeks of gestation may reduce the risk of cerebral palsy in their children. Six trials involving 4796 women and 5357 infants were included. Antenatal magnesium sulfate was associated with a significant reduction in the risk of cerebral palsy (relative risk [RR], 0.69; 95% confidence interval [CI], 0.55-0.88), moderate or severe cerebral palsy (RR, 0.64; 95% CI, 0.44-0.92), and substantial gross motor dysfunction (RR, 0.60; 95% CI, 0.43-0.83). There was no overall difference in the risk of total pediatric mortality (RR, 1.01; 95% CI, 0.89-1.14). Minor side effects were more frequent among women receiving magnesium sulfate. In conclusion, magnesium sulfate administered to women at risk of delivery before 34 weeks of gestation reduces the risk of cerebral palsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.