ArticleNeuroscience2009
Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels.
Article in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps.Muscle & nerve · 2017Trial
- Global Trends and Hotspots of Transient Receptor Potential Melastatin 8 Research from 2002 to 2021: A Bibliometric Analysis.Journal of pain research · 2022Article
- Growth at Cold Temperature Increases the Number of Motor Neurons to Optimize Locomotor Function.Current biology : CB · 2019Article
- Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.Journal of neurophysiology · 2017Review
- Modulatory and plastic effects of kinins on spinal cord networks.The Journal of physiology · 2016Article
- Essential oils in the treatment of respiratory tract diseases highlighting their role in bacterial infections and their anti-inflammatory action: a review.Flavour and fragrance journal · 2015Review
- Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Enabling techniques for in vitro studies on mammalian spinal locomotor mechanisms.Frontiers in bioscience (Landmark edition) · 2012Review
- Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Shining light into the black box of spinal locomotor networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- Long and short multifunicular projections of sacral neurons are activated by sensory input to produce locomotor activity in the absence of supraspinal control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Ion channels involved in cold detection in mammals: TRP and non-TRP mechanisms.Biophysical reviews · 2009Review
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
It is well recognized that proprioceptive afferent inputs can control the timing and pattern of locomotion. C and Adelta afferents can also affect locomotion but an unresolved issue is the identity of the subsets of these afferents that encode defined modalities. Over the last decade, the transient receptor potential (TRP) ion channels have emerged as a family of non-selective cation conductances that can label specific subsets of afferents. We focus on a class of TRPs known as ThermoTRPs which are well known to be sensor receptors that transduce changes in heat and cold. ThermoTRPs are known to help encode somatosensation and painful stimuli, and receptors have been found on C and Adelta afferents with central projections onto dorsal horn laminae. Here we show, using in vitro neonatal mouse spinal cord preparations, that activation of both spinal and peripheral transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential melastatin 8 (TRPM8) afferent terminals modulates central pattern generators (CPGs). Capsaicin or menthol and cooling modulated both sacrocaudal afferent (SCA) evoked and monoaminergic drug-induced rhythmic locomotor-like activity in spinal cords from wild type but not TRPV1-null (trpv1(-/-)) or TRPM8-null (trpm8(-/-)) mice, respectively. Capsaicin induced an initial increase in excitability of the lumbar motor networks, while menthol or cooling caused a decrease in excitability. Capsaicin and menthol actions on CPGs involved excitatory and inhibitory glutamatergic mechanisms, respectively. These results for the first time show that dedicated pathways of somatosensation and pain identified by TRPV1 or TRPM8 can target spinal locomotor CPGs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.