ArticleMolecular and cellular endocrinology2010
Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4).
Article in Molecular and cellular endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Humanized dopamine DJournal of neuroscience research · 2024Review
- Significant Functional Differences Between Dopamine DMolecular neurobiology · 2023Article
- Functional and pharmacological role of the dopamine DFrontiers in endocrinology · 2022Review
- Heteromerization between αPharmacological research · 2021Article
- The Circadian Oscillator of the Cerebellum: Triiodothyronine Regulates Clock Gene Expression in Granule CellsFrontiers in physiology · 2021Article
- A genome-wide DNA methylation analysis in peripheral blood from patients identifies risk loci associated with Graves' orbitopathy.Journal of endocrinological investigation · 2018Article
- Neuroendocrine Associations Underlying the Persistent Therapeutic Effects of Classic Serotonergic Psychedelics.Frontiers in pharmacology · 2018Review
- Daily Profiles of Neuropeptides, Catecholamines, and Neurotransmitter Receptors in the Chicken Pineal Gland.Frontiers in physiology · 2018Article
- Article
- Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin.Cellular signalling · 2015Article
- Noradrenaline upregulates T-type calcium channels in rat pinealocytes.The Journal of physiology · 2015Article
- Neurotranscriptomics: The Effects of Neonatal Stimulus Deprivation on the Rat Pineal Transcriptome.PloS one · 2015Article
- The melatonergic system in mood and anxiety disorders and the role of agomelatine: implications for clinical practice.International journal of molecular sciences · 2013Review
- Disease-specific heteromerization of G-protein-coupled receptors that target drugs of abuse.Progress in molecular biology and translational science · 2013Review
- Circadian changes in long noncoding RNAs in the pineal gland.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland.PLoS biology · 2012Article
- Pineal function: impact of microarray analysis.Molecular and cellular endocrinology · 2010Review
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
Dopamine plays diverse and important roles in vertebrate biology, impacting behavior and physiology through actions mediated by specific G-protein-coupled receptors, one of which is the dopamine receptor D4 (Drd4). Here we present studies on the >100-fold daily rhythm in rat pineal Drd4 expression. Our studies indicate that Drd4 is the dominant dopamine receptor gene expressed in the pineal gland. The gene is expressed in pinealocytes at levels which are approximately 100-fold greater than in other tissues, except the retina, in which transcript levels are similar. Pineal Drd4 expression is circadian in nature and under photoneural control. Whereas most rhythmically expressed genes in the pineal are controlled by adrenergic/cAMP signaling, Drd4 expression also requires thyroid hormone. This advance raises the questions of whether Drd4 expression is regulated by this mechanism in other systems and whether thyroid hormone controls expression of other genes in the pineal gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.