ArticleActa biomaterialia2010
The effect of complexation hydrogels on insulin transport in intestinal epithelial cell models.
Article in Acta biomaterialia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 58 citations in OpenAlex.
- Investigating the activation of the immune response by outer membrane vesicles from Bacteroides fragilis using a human gastrointestinal cell system.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles.Materials (Basel, Switzerland) · 2018Article
- Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery.Acta pharmaceutica Sinica. B · 2018Review
- Recent advances in hemophilia B therapy.Drug delivery and translational research · 2017Review
- Design of pH-Responsive Biomaterials to Enable the Oral Route of Hematological Factor IX.Annals of biomedical engineering · 2016Article
- Micro/nanofabricated platforms for oral drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Hybrid responsive hydrogel carriers for oral delivery of low molecular weight therapeutic agents.Journal of drug delivery science and technology · 2015Article
- Surface-modified P(HEMA-co-MAA) nanogel carriers for oral vaccine delivery: design, characterization, and in vitro targeting evaluation.Biomacromolecules · 2014Article
- Planar bioadhesive microdevices: a new technology for oral drug delivery.Current pharmaceutical biotechnology · 2014Review
- Permeation of insulin, calcitonin and exenatide across Caco-2 monolayers: measurement using a rapid, 3-day system.PloS one · 2013Article
- An inulin and doxorubicin conjugate for improving cancer therapy.Journal of drug delivery science and technology · 2013Article
- Microfabrication technologies for oral drug delivery.Advanced drug delivery reviews · 2012Review
- Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics.Journal of controlled release : official journal of the Controlled Release Society · 2011Article
- Cellular evaluation of synthesized insulin/transferrin bioconjugates for oral insulin delivery using intelligent complexation hydrogels.Macromolecular bioscience · 2010Article
- Micro- and nanotechnologies for intelligent and responsive biomaterial-based medical systems.Advanced drug delivery reviews · 2009Review
- Transport and delivery of interferon-α through epithelial tight junctions via pH-responsive poly(methacrylic acid-grafted-ethylene glycol) nanoparticles.Journal of drug targetingArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A novel class of pH-sensitive complexation hydrogels composed of methacrylic acid and functionalized poly(ethylene glycol) (PEG) tethers, referred to as P(MAA-g-EG) WGA, was investigated as an oral protein delivery system. The PEG tethers were functionalized with wheatgerm agglutinin (WGA), a lectin that can bind to carbohydrates in the intestinal mucosa, to improve residence time of the carrier and absorption of the drug at the delivery site. The ability of P(MAA-g-EG) WGA to improve insulin absorption was observed in two different intestinal epithelial models. In Caco-2 cells P(MAA-g-EG) WGA improved insulin permeability 9-fold as compared with an insulin only solution, which was similar to the improvement by P(MAA-g-EG). P(MAA-g-EG) and P(MAA-g-EG) WGA were also evaluated in a mucus-secreting culture that contained Caco-2 and HT29-MTX cells. Insulin permeability was increased 5-fold in the presence of P(MAA-g-EG) and P(MAA-g-EG) WGA. Overall, it is clear that P(MAA-g-EG) WGA enhances insulin absorption and holds great promise as an oral insulin delivery system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.