ArticleJournal of molecular and cellular cardiology2010
Molecular determinants of local anesthetic action of beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3.
Article in Journal of molecular and cellular cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Effectiveness of beta-blockers depending on the genotype of congenital long-QT syndrome: A meta-analysis.PloS one · 2017Pooled it
- Article
- Differential effects of non-selective and cardio-selective beta-blocker therapy on ECG parameters in long QT syndrome type 1.International journal of cardiology. Heart & vasculature · 2026Article
- The Prenatal Diagnosis and Perinatal Management of Congenital Long QT Syndrome: A Comprehensive Literature Review and Recent Updates.Journal of cardiovascular development and disease · 2025Review
- The proarrhythmogenic role of autonomics and emerging neuromodulation approaches to prevent sudden death in cardiac ion channelopathies.Cardiovascular research · 2024Review
- Carvedilol increases seizure resistance in a mouse model ofFrontiers in pharmacology · 2024Article
- Calculations of the binding free energies of the ComprehensiveBiophysics and physicobiology · 2023Article
- Mechanism of carvedilol induced action potential and calcium alternans.Channels (Austin, Tex.) · 2022Article
- Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers.Channels (Austin, Tex.) · 2022Article
- Resuscitated Sudden Cardiac Arrest of a Neonate with Congenital LQT Syndrome-Associated Torsades de Pointes: A Case Report and Literature Review.Journal of cardiovascular development and disease · 2022Article
- Diagnosis, management and therapeutic strategies for congenital long QT syndrome.Heart (British Cardiac Society) · 2022Review
- Cardiac potassium inward rectifier Kir2: Review of structure, regulation, pharmacology, and arrhythmogenesis.Heart rhythm · 2021Review
- Epirubicin-induced QT prolongation, monomorphic ventricular tachycardia, and response to beta blockade in long QT syndrome type 2.HeartRhythm case reports · 2020Article
- Effect of carvedilol on atrial excitation-contraction coupling, CaAmerican journal of physiology. Heart and circulatory physiology · 2020Article
- Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model.Frontiers in cell and developmental biology · 2020Article
- Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3.Frontiers in pharmacology · 2020Article
- Bioactivity Profile of the Diterpene Isosteviol and its Derivatives.Molecules (Basel, Switzerland) · 2019Review
- An Overview of Diagnosis and Management Strategies for Long QT Syndrome.The Journal of innovations in cardiac rhythm management · 2017Review
- Molecular Pathophysiology of Congenital Long QT Syndrome.Physiological reviews · 2017Review
- A high-risk patient with long-QT syndrome with no response to cardioselective beta-blockers.Heart and vessels · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The congenital long QT syndrome (LQTS) is a heritable arrhythmia in which mutations in genes coding for ion channels or ion channel associated proteins delay ventricular repolarization and place mutation carriers at risk for serious or fatal arrhythmias. Triggers and therapeutic management of LQTS arrhythmias have been shown to differ in a manner that depends strikingly on the gene that is mutated. Additionally, beta-blockers, effective in the management of LQT-1, have been thought to be potentially proarrhythmic in the treatment of LQT-3 because of concomitant slowing of heart rate that accompanies decreased adrenergic activity. Here we report that the beta-blocker propranolol interacts with wild type (WT) and LQT-3 mutant Na(+) channels in a manner that resembles the actions of local anesthetic drugs. We demonstrate that propranolol blocks Na(+) channels in a use-dependent manner; that propranolol efficacy is dependent on the inactivated state of the channel; that propranolol blocks late non-inactivating current more effectively than peak sodium current; and that mutation of the local anesthetic binding site greatly reduces the efficacy of propranolol block of peak and late Na(+) channel current. Furthermore our results indicate that this activity, like that of local anesthetic drugs, differs both with drug structure and the biophysical changes in Na(+) channel function caused by specific LQT-3 mutations.
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