ArticleImmunity & ageing : I & A2009
Adverse environmental conditions influence age-related innate immune responsiveness.
Article in Immunity & ageing : I & A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Ecoimmunology in the field: Measuring multiple dimensions of immune function with minimally invasive, field-adapted techniques.American journal of human biology : the official journal of the Human Biology Council · 2022Review
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- Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
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- Cardiovascular disease and type 2 diabetes in evolutionary perspective: a critical role for helminths?Evolution, medicine, and public health · 2016Review
- Variants of the IL-10 gene associate with muscle strength in elderly from rural Africa: a candidate gene study.Aging cell · 2014Article
- Scarcity of atrial fibrillation in a traditional African population: a community-based study.BMC cardiovascular disorders · 2014Article
- Influence of endogamy and mitochondrial DNA on immunological parameters in cattle.BMC veterinary research · 2014Article
- The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).Molecular psychiatry · 2013Article
- Lead concentrations in relation to multiple biomarkers of cardiovascular disease: the Normative Aging Study.Environmental health perspectives · 2012Article
- Risk of cardiovascular disease in a traditional African population with a high infectious load: a population-based study.PloS one · 2012Article
- Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load.Biodemography and social biology · 2011Article
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe innate immune system plays an important role in the recognition and induction of protective responses against infectious pathogens, whilst there is increasing evidence for a role in mediating chronic inflammatory diseases at older age. Despite indications that environmental conditions can influence the senescence process of the adaptive immune system, it is not known whether the same holds true for the innate immune system. Therefore we studied whether age-related innate immune responses are similar or differ between populations living under very diverse environmental conditions.
methodsWe compared cross-sectional age-related changes in ex vivo innate cytokine responses in a population living under affluent conditions in the Netherlands (age 20-68 years old, n = 304) and a population living under adverse environmental conditions in Ghana (age 23-95 years old, n = 562).
resultsWe found a significant decrease in LPS-induced Interleukin (IL)-10 and Tumor Necrosis Factor (TNF) production with age in the Dutch population. In Ghana a similar age-related decline in IL-10 responses to LPS, as well as to zymosan, or LPS plus zymosan, was observed. TNF production, however, did not show an age-associated decline, but increased significantly with age in response to co-stimulation with LPS and zymosan.
conclusionWe conclude that the decline in innate cytokine responses is an intrinsic ageing phenomenon, while pathogen exposure and/or selective survival drive pro-inflammatory responses under adverse living conditions.
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