ArticleBMC medical genetics2009
Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations.
Article in BMC medical genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Low testosterone concentrations and prediction of future heart failure in men and in women: evidence from the large FINRISK97 study.ESC heart failure · 2021Article
- Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study.Scientific reports · 2021Article
- Iron Metabolism Contributes to Prognosis in Coronary Artery Disease: Prognostic Value of the Soluble Transferrin Receptor Within the AtheroGene Study.Journal of the American Heart Association · 2020Article
- Predictive value of low testosterone concentrations regarding coronary heart disease and mortality in men and women - evidence from the FINRISK97 study.Journal of internal medicine · 2019Article
- Article
- Biomarkers Related to Carotid Intima-Media Thickness and Plaques in Long-Term Survivors of Ischemic Stroke.Translational stroke research · 2015Article
- Fcγ receptors and ligands and cardiovascular disease.Circulation research · 2015Review
- Platelet receptor polymorphisms do not influence Staphylococcus aureus-platelet interactions or infective endocarditis.Microbes and infection · 2011Article
- CRP in cardiovascular disease.Herz · 2009Article
- Neuronal thread protein regulation and interaction with microtubule-associated proteins in SH-Sy5y neuronal cells.Cellular and molecular life sciences : CMLS · 2003Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the Fc gamma receptor IIa (Fc gamma RIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear. We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples.
methodsFc gamma RIIa-R/H131 polymorphisms were determined in a population of 527 patients with a history of myocardial infarction and 527 age and gender matched controls drawn from a population-based MONICA- Augsburg survey. In the LURIC population, 2227 patients with angiographically proven CHD, defined as having at least one stenosis >or= 50%, were compared with 1032 individuals with stenosis <50%.
resultsIn both populations genotype frequencies of the Fc gamma RIIa gene did not show a significant departure from the Hardy-Weinberg equilibrium. Fc gamma RIIa R(-131) --> H genotype was not independently associated with lower risk of CHD after multivariable adjustments, neither in the MONICA population (odds ratio (OR) 1.08; 95% confidence interval (CI) 0.81 to 1.44), nor in LURIC (OR 0.96; 95% CI 0.81 to 1.14).
conclusionOur results do not confirm an independent relationship between Fc gamma RIIa genotypes and risk of CHD in these populations.
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