Evidence map›Paper›PMID 19480389›Full record

ReviewChemical reviews2009

IMP dehydrogenase: structure, mechanism, and inhibition.

Lizbeth Hedstrom

Abstract readReview
In one paragraph

Review in Chemical reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers.

0numbers the graph read from it
0cells of the map it votes in
210citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

210 citing papers in PubMed.

  1. Article
  2. GTP biosynthesis is a therapeutic vulnerability in Rac1-mutant melanoma.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. In thePNAS nexus · 2026
    Article
  9. Article
  10. Review
  11. ExploringAntimicrobial agents and chemotherapy · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. An IMPDH2 variant associated with neurodevelopmental disorder disrupts purine biosynthesis and somite organization.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Article
  20. Article

150 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Lizbeth HedstromDepartment of Biology, Brandeis University, MS009, 415 South Street, Waltham, Massachusetts 02454, USA. hedstrom@brandeis.edu

Funding

XRAY CRYSTALLOGRAPHIC STRUCTURE ANALYSIS: PROTEIN SORTINGP41RR001081 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 1985 to 2011
$17.6M
INOSINE MONOPHOSPHATE DEHYDROGENASER01GM054403 · NIGMS · BRANDEIS UNIVERSITY · PI HEDSTROM, LIZBETH K. · 1998 to 2016
$4.2M
NCRR NIH HHS P41 RR001081NCRR NIH HHS P41 RR-01081NIGMS NIH HHS GM54403NIGMS NIH HHS R01 GM054403
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Catalytic DomainEnzyme InhibitorsHumansIMP DehydrogenaseKineticsNeoplasmsProtein Structure, TertiarySubstrate SpecificityEnzyme InhibitorsIMP Dehydrogenase

Identifiers

PMID19480389
PMCPMC2737513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.