ReviewPulmonary pharmacology & therapeutics2009
Cough and viruses in airways disease: mechanisms.
Review in Pulmonary pharmacology & therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children with colds: a randomized, single-blinded, multicenter study.World journal of pediatrics : WJP · 2017Trial
- Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold.Respiratory research · 2010Trial
- Sulfolipid-1 fromJournal of neurophysiology · 2026Article
- Activity and mechanism of naringin in the treatment of post-infectious cough.BMC pulmonary medicine · 2025Article
- Article
- Infections including SARS-CoV-2 as triggers for vocal cord dysfunction.The journal of allergy and clinical immunology. In practice · 2024Article
- Risk factors contributing to impaired cough-specific quality of life at the time of admission for coronavirus disease 2019 treatment.Journal of thoracic disease · 2022Article
- Effects of Pelargonium sidoides extract EPs 7630 on acute cough and quality of life - a meta-analysis of randomized, placebo-controlled trials.Multidisciplinary respiratory medicine · 2022Article
- IAPV-Induced Paralytic Symptoms Associated with Tachypnea via Impaired Tracheal System Function.International journal of molecular sciences · 2021Article
- Potentials of Antitussive Traditional Persian Functional Foods for COVID-19 TherapyFrontiers in pharmacology · 2021Review
- Article
- Article
- The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics.Respiratory research · 2018Review
- Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice.Journal of ethnopharmacology · 2018Article
- Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells.PloS one · 2017Article
- Review
- Targeting TRP channels for chronic cough: from bench to bedside.Naunyn-Schmiedeberg's archives of pharmacology · 2015Review
- Effect of viral upper respiratory tract infection on cough reflex sensitivity.Journal of thoracic disease · 2014Review
- Antitussive drugs--past, present, and future.Pharmacological reviews · 2014Review
- PCR based bronchoscopic detection of common respiratory pathogens in chronic cough: a case control study.Cough (London, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute cough is a major symptom of viral respiratory tract infection and causes excessive morbidity in human populations across the world. A wide variety of viruses play a role in the development of cough after acute infection and all of these manifest a similar clinical picture across different age groups. Despite the large disease burden surprisingly little is known about the mechanism of acute cough following viral infection. Both in vitro and in vivo experiments show that increased production of neuropeptides and leukotrienes mediate cough after viral infection, along with altered expression of neural receptors. Increased airway mucus production is also likely to play a significant role. This work is reviewed in this article. Following the recent development of a mouse model for rhinovirus infection and the establishment of experimental models of rhinovirus challenge in human subjects with both asthma and COPD the field is expanding to translate in vitro research into clinical studies and hopefully eventually into clinical practice. Developing a clearer understanding of the mechanisms underlying virus induced cough may lead to more specific and effective therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.