ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- ProteinMolecules (Basel, Switzerland) · 2025Review
- Article
- Genetics of glycosylation in mammalian development and disease.Nature reviews. Genetics · 2024Review
- Hindbrain boundaries as niches of neural progenitor and stem cells regulated by the extracellular matrix proteoglycan chondroitin sulphate.Development (Cambridge, England) · 2024Article
- In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2.The Journal of biological chemistry · 2023Article
- Modulation of the NOTCH1 Pathway by LUNATIC FRINGE Is Dominant over That of MANIC or RADICAL FRINGE.Molecules (Basel, Switzerland) · 2021Article
- Multifaceted regulation of Notch signaling by glycosylation.Glycobiology · 2021Review
- Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.The Journal of biological chemistry · 2020Article
- Decoding the PTM-switchboard of Notch.Biochimica et biophysica acta. Molecular cell research · 2019Review
- Protein O-fucosylation: structure and function.Current opinion in structural biology · 2019Review
- Roles for Golgi Glycans in Oogenesis and Spermatogenesis.Frontiers in cell and developmental biology · 2019Review
- Multiple roles for O-glycans in Notch signalling.FEBS letters · 2018Review
- Evolutionary emergence of theProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis.eLife · 2018Article
- Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.Developmental cell · 2017Article
- Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.eLife · 2016Article
- What Have We Learned from Glycosyltransferase Knockouts in Mice?Journal of molecular biology · 2016Review
- Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Sequential Notch activation regulates ventricular chamber development.Nature cell biology · 2016Article
- The multiple roles of epidermal growth factor repeat O-glycans in animal development.Glycobiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Tight regulation of Notch pathway signaling is important in many aspects of embryonic development. Notch signaling can be modulated by expression of fringe genes, encoding glycosyltransferases that modify EGF repeats in the Notch receptor. Although Lunatic fringe (Lfng) has been shown to play important roles in vertebrate segmentation, comparatively little is known regarding the developmental functions of the other vertebrate fringe genes, Radical fringe (Rfng) and Manic fringe (Mfng). Here we report that Mfng expression is not required for embryonic development. Further, we find that despite significant overlap in expression patterns, we detect no obvious synergistic defects in mice in the absence of two, or all three, fringe genes during development of the axial skeleton, limbs, hindbrain, and cranial nerves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.