ReviewCell motility and the cytoskeleton2009
The hard life of soft cells.
Review in Cell motility and the cytoskeleton, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 166 citations in OpenAlex.
- Nanomechanical Hallmarks ofInternational journal of molecular sciences · 2021Trial
- Evolving Data-Driven Strategies for the Characterization of Supramolecular Polymers and Systems.Angewandte Chemie (International ed. in English) · 2025Review
- Mechanical Properties of Inflamed Appendix Tissues.Biomedicines · 2024Article
- Progress in Stem Cells-Based Replacement Therapy for Retinal Pigment Epithelium: In Vitro Differentiation to In Vivo Delivery.Stem cells translational medicine · 2023Review
- Tissutal and Fluidic Aspects in Osteopathic Manual Therapy: A Narrative Review.Healthcare (Basel, Switzerland) · 2022Review
- Cathelicidin LL-37 in Health and Diseases of the Oral Cavity.Biomedicines · 2022Review
- Growth of MIN-6 Cells on Salmon Fibrinogen Scaffold Improves Insulin Secretion.Pharmaceutics · 2022Article
- Is polydopamine beneficial for cells on the modified surface?Regenerative biomaterials · 2022Article
- Hydrogel-Supported, Engineered Model of Vocal Fold Epithelium.ACS biomaterials science & engineering · 2021Article
- Accounting for Material Changes in Decellularized Tissue with Underutilized Methodologies.BioMed research international · 2021Review
- Development of Nascent Focal Adhesions in Spreading Cells.Biophysical journal · 2020Review
- Tissue Rheology as a Possible Complementary Procedure to Advance Histological Diagnosis of Colon Cancer.ACS biomaterials science & engineering · 2020Article
- A minimal mechanosensing model predicts keratocyte evolution on flexible substrates.Journal of the Royal Society, Interface · 2020Article
- Poly-l-Lactic Acid Nanotubes as Soft Piezoelectric Interfaces for Biology: Controlling Cell AttachmentACS applied bio materials · 2020Article
- Mechanosensitivity Occurs along the Adhesome's Force Train and Affects Traction Stress.Biophysical journal · 2019Article
- Physical and functional cell-matrix uncoupling in a developing tissue under tension.Development (Cambridge, England) · 2019Article
- Biomimetic Designer Scaffolds Made of D,L-Lactide-Tissue engineering. Part B, Reviews · 2019Review
- Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction.The Journal of cell biology · 2018Article
- Substrate Stiffness Influences the Time Dependence of CTGF Protein Expression in Müller Cells.International physiology journal · 2018Article
- Size- and speed-dependent mechanical behavior in living mammalian cytoplasm.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cells are mechanical as well as chemical machines, and much of the energy they consume is used to apply forces to each other and to the extracellular matrix around them. The cytoskeleton, the cell membrane, and the macromolecules composing the extracellular matrix form networks that in concert with the forces generated by the cell create dynamic materials with viscoelastic properties unique to each tissue. Numerous recent studies suggest that the forces that cells create and are subjected to, as well as the mechanical properties of the materials to which they adhere, can have large effects on cell structure and function that can act in concert with or override signals from soluble stimuli. This brief review summarizes recent studies of the effects of substrate mechanics on cell motility, differentiation, and proliferation, and discusses possible mechanisms by which a cell can probe the stiffness of its surroundings. Cell Motil. Cytoskeleton, 2009. (c) 2009 Wiley-Liss, Inc.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.