ArticleNaunyn-Schmiedeberg's archives of pharmacology2009
Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Anti-Hyperalgesic Effect of Isopulegol Involves GABA and NMDA Receptors in a Paclitaxel-Induced Neuropathic Pain Model.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- Secondary Terpenes inBiomedicines · 2022Review
- The Effect of Metformin on Ethanol- and IndomethacinInduced Gastric Ulcers in Rats.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Chemical constituents and gastro-protective potential of Pachira glabra leaves against ethanol-induced gastric ulcer in experimental rat model.Inflammopharmacology · 2021Article
- Determination of the Chemical Composition and Antimicrobial Activity ofInternational journal of biomaterials · 2021Article
- UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential ofMolecules (Basel, Switzerland) · 2020Article
- Antiedematogenic and Anti-Inflammatory Activity of the Monoterpene Isopulegol and Its β-Cyclodextrin (β-CD) Inclusion Complex in Animal Inflammation Models.Foods (Basel, Switzerland) · 2020Article
- Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats.BMC complementary and alternative medicine · 2019Article
- Protective activity of geraniol against acetic acid andJournal of traditional and complementary medicine · 2019Article
- Assessment of Antisecretory, Gastroprotective, and In-vitro Antacid Potential of Daucus carota in Experimental Rats.Osong public health and research perspectives · 2015Article
- The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K ATP Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Anti-ulcer activity of essential oil constituents.Molecules (Basel, Switzerland) · 2014Review
- Geraniol-a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Banhabaekchulchunma-tang, a traditional herbal formula attenuates absolute ethanol-induced gastric injury by enhancing the antioxidant status.BMC complementary and alternative medicine · 2013Article
- Gastroprotective effects of Leejung-tang, an oriental traditional herbal formula, on ethanol-induced acute gastric injury in rats.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2013Article
- Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- Protective effects of the traditional herbal formula oryeongsan water extract on ethanol-induced acute gastric mucosal injury in rats.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Anti-nociceptive and anti-inflammatory activities of (-)-α-bisabolol in rodents.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- Spices, herbal xenobiotics and the stomach: friends or foes?World journal of gastroenterology · 2010Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated whether isopulegol, a monoterpene present in essential oils of several aromatic plants, would be able to promote some gastroprotective effect and also verified the possible mechanisms involved in this action. For this study, ethanol- and indomethacin-induced gastric ulcer models in mice and histopathological assessment were used. The roles of NO, sulfhydryls (glutathione, GSH), ATP-sensitive K(+) channels (K(ATP) channels), and prostaglandins were also investigated. Isopulegol exhibited a dose-related gastroprotective effect against ethanol-induced lesions, while the pretreatment with glibenclamide and indomethacin [but not with N(G)-nitro-L-arginine methyl ester] were able to reverse this action. The pretreatment with isopulegol also restored GSH levels to normal levels and exhibited dose-related gastroprotective effect against indomethacin-induced ulcer. The results suggested that isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.