ArticleEnvironmental health perspectives2009
Predictors of endotoxin levels in U.S. housing.
Article in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- The relationship of domestic pet ownership with the risk of childhood asthma: A systematic review and meta-analysis.Frontiers in pediatrics · 2022Pooled it
- Trial
- TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.The Journal of clinical investigation · 2015Trial
- Indoor allergens and endotoxins in relation to cockroach infestations in low-income urban homes.The journal of allergy and clinical immunology. Global · 2026Article
- Indoor allergen exposure and its association to upper respiratory infections and pulmonary outcomes among children with asthma.The Journal of allergy and clinical immunology · 2024Article
- Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants.Environmental science & technology · 2023Article
- Indoor environmental exposures and obstructive lung disease phenotypes among children with asthma living in poor urban neighborhoods.The Journal of allergy and clinical immunology · 2023Article
- Article
- Bioaerosol and microbial exposures from residential evaporative coolers and their potential health outcomes: A review.Indoor air · 2022Review
- Comparing the concentration levels of allergens and endotoxins in employees' homes and offices.International archives of occupational and environmental health · 2022Article
- Indoor endotoxin, proximity to a major roadway, and severe asthma exacerbations among children in Puerto Rico.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Article
- Endotoxin clustering with allergens in house dust and asthma outcomes in a U.S. national study.Environmental health : a global access science source · 2020Article
- Endotoxin, food allergen sensitization, and food allergy: A complementary epidemiologic and experimental study.Allergy · 2020Article
- Pet-Keeping in Relation to Asthma, Rhinitis, and Eczema Symptoms Among Adolescents in Kuwait: A Cross-Sectional Study.Frontiers in pediatrics · 2020Article
- Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes.American journal of respiratory and critical care medicine · 2019Article
- Rhinoconjunctivitis among Adolescents in Kuwait and Associated Risk Factors: A Cross-Sectional Study.BioMed research international · 2019Article
- House Dust Endotoxin Association with Chronic Bronchitis and Emphysema.Environmental health perspectives · 2018Article
- Endotoxin predictors and associated respiratory outcomes differ with climate regions in the U.S.Environment international · 2018Article
- Reducing indoor air pollutants with air filtration units in wood stove homes.The Science of the total environment · 2017Article
- House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies.Environmental health perspectives · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe relationship of domestic endotoxin exposure to allergy and asthma has been widely investigated. However, few studies have evaluated predictors of household endotoxin, and none have done so for multiple locations within homes and on a national scale.
objectivesWe assayed 2,552 house dust samples in a nationwide study to understand the predictors of household endotoxin in bedroom floors, family room floors, beds, kitchen floors, and family room sofas.
methodsReservoir house dust from five locations within homes was assayed for endotoxin and demographic and housing information was assessed through questionnaire and onsite evaluation of 2,456 residents of 831 homes selected to represent national demographics. We performed repeated-measures analysis of variance (rANOVA) for 37 candidate variables to identify independent predictors of endotoxin. Meteorologic data were obtained for each primary sampling unit and tested as predictors of indoor endotoxin to determine if wetter or warmer microclimates were associated with higher endotoxin levels.
resultsWeighted geometric mean endotoxin concentration ranged from 18.7 to 80.5 endotoxin units (EU)/mg for the five sampling locations, and endotoxin load ranged from 4,160 to 19,500 EU/m(2). Bivariate analyses and rANOVA demonstrated that major predictors of endotoxin concentration were sampling location in the home, census division, educational attainment, presence of children, current dog ownership, resident-described problems with cockroaches, food debris, cockroach stains, and evidence of smoking observed by field staff. Low household income entered the model if educational attainment was removed.
conclusionIncreased endotoxin in household reservoir dust is principally associated with poverty, people, pets, household cleanliness, and geography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.