ArticleThe open ophthalmology journal2007
Identification and functional distribution of intracellular ca channels in mouse lacrimal gland acinar cells.
Article in The open ophthalmology journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Ion channels in dry eye disease.Indian journal of ophthalmology · 2023Review
- Differential subcellular Ca2+ signaling in a highly specialized subpopulation of astrocytes.Experimental neurology · 2015Article
- Calcium signaling in lacrimal glands.Cell calcium · 2014Review
- P2Y purinoceptors induce changes in intracellular calcium in acinar cells of rat lacrimal glands.Histochemistry and cell biology · 2012Article
- Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains.Experimental eye research · 2011Article
- Polycystin-2 expression and function in adult mouse lacrimal acinar cells.Investigative ophthalmology & visual science · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have determined the presence and cellular distribution of intracellular calcium channels, inositol 1, 4, 5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs) in adult and postnatal (P10) lacrimal gland acinar cells. Western blot analysis of both P10 cultures and adult tissue identified the presence of each IP(3)R and RyR isotypes. The immunocytochemistry analysis showed a differential cellular distribution of these calcium channels where the nuclear envelope, endoplasmic reticulum (ER) and Golgi apparatus membranes represent areas with highest levels of channel expression. This IP(3)R and RyR isotype distribution is confirmed by the immuno-EM results. The findings described in this study are in agreement with published pharmacological data that shows the participation of these channels in the secretion process of the lacrimal gland acinar cells. Furthermore, the differential subcellular distribution between the isoforms could indicate a potential role of these intracellular Ca(2+ )channels on the regulation of specific cellular functions.
Identifiers
What OpenQuestion holds
Registered trials
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