ArticleMelanoma research2009
Nuclear PTEN levels and G2 progression in melanoma cells.
Article in Melanoma research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.Cell cycle (Georgetown, Tex.) · 2018Article
- Nuclear phosphoinositide regulation of chromatin.Journal of cellular physiology · 2018Review
- Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair.Frontiers in oncology · 2014Review
- ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.Archives of dermatological research · 2013Article
- Utility of PTEN protein dosage in predicting for underlying germline PTEN mutations among patients presenting with thyroid cancer and Cowden-like phenotypes.The Journal of clinical endocrinology and metabolism · 2012Article
- PTEN inhibits proliferation and functions of hypertrophic scar fibroblasts.Molecular and cellular biochemistry · 2012Article
- Nongenomic Mechanisms of PTEN Regulation.International journal of cell biology · 2012Article
- PTEN level in tumor suppression: how much is too little?Cancer research · 2011Review
- Effect of wild type PTEN gene on proliferation and invasion of multiple myeloma.International journal of hematology · 2010Article
- PTEN inhibits BMI1 function independently of its phosphatase activity.Molecular cancer · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
The phosphatase and tensin homolog (PTEN) exerts its function, in part, by negatively regulating the well-known phosphatidylinositol-3-kinase/AKT signaling pathway. Previous histological work has suggested that alterations in the nuclear/cytoplasmic compartmentalization of PTEN may play a role in the development and progression of melanoma. In this study, we examined the nuclear/cytoplasmic compartmentalization of PTEN in melanoma cell lines and its correlation with the cell cycle. Studies were performed in melanoma cells lines using classic cell biological techniques. In contrast to breast cancer cell lines, we found that increased levels of nuclear PTEN levels correlate with G2 rather than with G1 arrest. In WM164 and SKmel28 cells, overexpression of PTEN protein did not significantly increase the number of cells in the G2 phase. Differential CDC2 phosphorylation levels in cells that overexpressed PTEN compared with those where PTEN was downregulated suggest some involvement of PTEN in G2 checkpoint regulation. The data suggest that although nuclear PTEN levels correlate with the G2 phase, the role of PTEN in modulating G2/M arrest is not limiting. Further, the specific cell cycle phase regulated by nuclear PTEN is cell-type dependent. Taken together, our observations suggest that in melanoma, nuclear PTEN is involved in G2 progression possibly through the modulation of CDC2, opening up a new arena for investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.