ArticleThe American journal of tropical medicine and hygiene2009
Utility of a protein fraction with cathepsin L-Like activity purified from cysticercus fluid of Taenia solium in the diagnosis of human cysticercosis.
Article in The American journal of tropical medicine and hygiene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- An Integrated Approach of Proteomic, Cheminformatic, and In Vitro Drug Screening to Identify Potential Therapeutic Targets ofACS omega · 2025Article
- Molecular characterization of EcCLP1, a new putative cathepsin L protease from Echinococcus canadensis.Parasite (Paris, France) · 2024Article
- Novel CRISPR-based detection ofFrontiers in microbiology · 2022Article
- Characterization of a novel cathepsin L-like protease from Taenia solium metacestodes for the immunodiagnosis of porcine cysticercosis.Veterinary parasitology · 2019Article
- The immunological characteristics and probiotic function of recombinant Bacillus subtilis spore expressing Clonorchis sinensis cysteine protease.Parasites & vectors · 2016Article
- Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR).Scientific reports · 2015Article
- Immunological and molecular diagnosis of cysticercosis.Pathogens and global health · 2012Review
- The highly antigenic 53/25 kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigs.Veterinary immunology and immunopathology · 2012Article
- TsAg5, a Taenia solium cysticercus protein with a marginal trypsin-like activity in the diagnosis of human neurocysticercosis.Molecular and biochemical parasitology · 2011Article
- Cysticercus cellulosae antigens in the serodiagnosis of neurocysticercosis.Tropical parasitology · 2011Article
- A dot-ELISA using a partially purified cathepsin-L-like protein fraction from Taenia solium cysticerci, for the diagnosis of human neurocysticercosis.Annals of tropical medicine and parasitology · 2011Article
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14 authors at 3 institutions in 2 countries.
Funding
Abstract
Neurocysticercosis, an endemic parasitic disease in most developing countries, is caused by Taenia solium and compromises the human central nervous system. Cathepsin L-like proteases are secreted by several parasites including T. solium and constitute important antigens for immunodiagnostics. A protein fraction with cathepsin L-like activity was purified from the cysticercus fluid by size exclusion and ion exchange chromatography. Cathepsin L-like activity was measured fluorometrically by detecting the hydrolysis of the fluorogenic substrate Z-Phe-Arg-AMC. The purified protein fraction included antigens of 53 and 25 kD that were tested in a Western immunoblot and in an enzyme-linked immunosorbent assay (ELISA) for detection of human cysticercosis. The sensitivity of the Western immunoblot was 96% for patients infected with multiple cysts and 78% for patients with a single cyst. Specificity was 98%. The sensitivity of the ELISA was 98% in patients with multiple cysts and 84% in patients with a single cyst. Specificity was 92.7%.
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Identifiers
19478259PMC2762273W2136943928What OpenQuestion holds
Registered trials
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