ArticlePhysiology & behavior2009
Stable behavioral inhibition and glucocorticoid production as predictors of longevity.
Article in Physiology & behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?Frontiers in neuroendocrinology · 2020Pooled it
- Cell Senescence and Central Regulators of Immune Response.International journal of molecular sciences · 2022Review
- Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits.International journal of molecular sciences · 2022Article
- A physiological profile approach to animal temperament: How to understand the functional significance of individual differences in behaviour.Proceedings. Biological sciences · 2022Review
- Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats.Physiology & behavior · 2020Article
- Group housing during adolescence has long-term effects on the adult stress response in female, but not male, zebra finches (Taeniopygia guttata).General and comparative endocrinology · 2018Article
- Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats.Hormones and behavior · 2014Article
- Long-term changes in cognitive bias and coping response as a result of chronic unpredictable stress during adolescence.Frontiers in human neuroscience · 2013Article
- Immune function and HPA axis activity in free-ranging rhesus macaques.Physiology & behavior · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Several personality/temperament traits have been linked to health outcomes in humans and animals but underlying physiological mechanisms for these differential outcomes are minimally understood. In this paper, we compared the strength of a behavioral trait (behavioral inhibition) and an associated physiological trait (glucocorticoid production) in predicting life span. In addition, we examined the relative stability of both the behavioral and physiological traits within individuals over a significant portion of adulthood, and tested the hypothesis that a stable behavioral trait is linked with a stable physiological bias. In a sample of 60 Sprague-Dawley male rats, we found that stable inhibition/neophobia was a stronger predictor of life span than stably elevated glucocorticoid production. In addition, these predictors appeared to have an additive influence on life span in that males with both risk factors (stable inhibition and consistently high glucocorticoid production) had the shortest life spans of all, suggesting both traits are important predictors of life span. Across a 4-month period in young adulthood, inhibition and glucocorticoid reactivity were relatively stable traits, however these two traits were not highly correlated with one another. Interestingly, baseline glucocorticoid production was a better predictor of life span than reactivity levels. The results indicate that glucocorticoid production in young adulthood is an important predictor of life span, although not as strong a predictor as inhibition, and that other physiological processes may further explain the shortened life span in behaviorally-inhibited individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.