Evidence map›Paper›PMID 19477055›Full record

ReviewVaccine2009

Biology and pathogenesis of the evolutionarily successful, obligate human bacterium Neisseria meningitidis.

David S Stephens

Open access · greenAbstract readReview
In one paragraph

Review in Vaccine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 193 citations in OpenAlex.

  1. Pooled it
  2. Carriage prevalence of Neisseria meningitidis in the Americas in the 21st century: a systematic review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Pooled it
  3. Trial
  4. Trial
  5. Isolation ofMicroorganisms · 2026
    Article
  6. Molecular characterization of Neisseria meningitidis isolates from healthy individuals in Meigu County, Sichuan Province, 2021-2024.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  7. Article
  8. Article
  9. Internalization ofMicroorganisms · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Preventing invasive meningococcal disease in early infancy.Human vaccines & immunotherapeutics · 2022
    Review
  16. Multilayer Regulation ofMicroorganisms · 2022
    Article
  17. Mechanical Activation of the βFrontiers in endocrinology · 2022
    Review
  18. Article
  19. Lactate-Induced Dispersal ofInfection and immunity · 2021
    Article
  20. Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

David S StephensEmory University, Robert W. Woodruff Health Sciences Center, 1440 Clifton Road, NE, Atlanta, GA 30322, USA. dstep01@emory.edu
Woodruff Health Sciences Center · US

Funding

MENINGOCOCCAL LIPOOLIGOSACCHARIDE &MUCOSAL PATHOGENESISR01AI033517 · NIAID · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 1993 to 2007
$1.7M
REGULATION OF CAPSULE BIOSYNTHESIS IN N MENINGITIDISR01AI040247 · NIAID · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 1997 to 2006
$1.2M
NIAID NIH HHS R01 AI033517NIAID NIH HHS R01 AI040247
6 · The paper itself

Abstract

For at least two hundred years, Neisseria meningitidis (the meningococcus), the cause of epidemic meningitis and sepsis, has inflicted rapid death, disability and fear on disparate human populations. The meningococcus is also recognized as a highly successful commensal organism exclusively found in humans. The evolution of N. meningitidis as an exclusive human commensal and sometimes a fulminant and fatal pathogen represents an important case study in microbial pathogenesis. We review the general status of our knowledge of pathogenesis of meningococcal carriage, transmission and virulence behavior with particular emphasis on the relevance of research on this topic to vaccine development.

Indexed as

Carrier StateHumansMeningococcal InfectionsMeningococcal VaccinesNeisseria meningitidisVirulenceMeningococcal Vaccines

Identifiers

PMID19477055
PMCPMC2712446
OpenAlexW2164450255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.