ArticleBrain pathology (Zurich, Switzerland)2010
Neuropathogenesis of naturally occurring encephalitis caused by Listeria monocytogenes in ruminants.
Article in Brain pathology (Zurich, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Early trigeminal nerve involvement in Listeria monocytogenes rhombencephalitis: case series and systematic review.Journal of neurology · 2017Pooled it
- Listeria monocytogenes septicemia and fetal maceration in long-tailed chinchillas (Chinchilla laniger) in Argentina.Veterinary research communications · 2026Article
- Natural intoxication by Solanum bonariense causing cerebellar neurodegeneration in cattle in Argentina.Veterinary research communications · 2026Article
- Horizontal Gene Transfer inBiology · 2026Review
- Synergistic Roles of InlA, InlB and LLO in the Infection of Trigeminal Ganglion Neurons by Ovine-DerivedAnimals : an open access journal from MDPI · 2026Article
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- Blood-Brain Barrier Penetration of Novel 4-Trifluoromethyl-Coumarin Hybrids with Antibacterial Properties as Potential Brain Therapeutics in the Context of Spatially Diverse Healthcare Systems.International journal of molecular sciences · 2025Article
- Listeriosis.Nature reviews. Disease primers · 2025Review
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- Divergent host-pathogen interactions in neurolisteriosis: cytosolic replication vs. phagosomal dormancy of Listeria monocytogenes in CNS macrophages.Acta neuropathologica · 2025Article
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- Identification and characterization of Listeria monocytogenes and Listeria innocua in bovine listeriosis cases in Uruguay.Tropical animal health and production · 2025Article
- Comparison of fluorescent antibody test, immunohistochemistry, and PCR testing for diagnostic confirmation of neurolisteriosis in 25 goats.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Bovine astrovirus and its role in lymphocytic encephalitis in cattle in Ontario, Canada, 1988-2019.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Rapport de cas Mononuclear pleocytosis and meningoencephalitis caused byThe Canadian veterinary journal = La revue veterinaire canadienne · 2023Article
- Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors.Journal of neuroinflammation · 2022Article
- Co-Infection ofMicroorganisms · 2022Article
- A novel enterovirus in lambs with poliomyelitis and brain stem encephalitis.Transboundary and emerging diseases · 2022Article
- The Viable But Non-Culturable State ofFrontiers in cellular and infection microbiology · 2022Review
- Fatal suppurative meningoencephalitis caused by Klebsiella pneumoniae in two calves.The Journal of veterinary medical science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeriosis is a serious food-borne disease with increasing frequency in humans and ruminants. Despite the facts that in both hosts, listeriosis can occur as rhombencephalitis and ruminants are a reservoir of Listeria monocytogenes (LM) strains pathogenic for humans, little work has been done on the pathogenesis in ruminants. This study investigates the neuropathogenesis of listeric encephalitis in over 200 natural cases in cattle, sheep and goats by analyzing anatomical distribution, severity, bacterial load and temporal evolution of the lesions. Our results suggest that LM gains access to the brainstem of all three species via axonal migration not only along the trigeminal nerve, but also along other nerves. The ensuing encephalitis does not remain restricted to the brainstem. Rather, LM spreads further from the brainstem into rostral brain regions likely by intracerebral axonal migration. Significant differences in severity of the lesions and bacterial load were found between cattle and small ruminants, which may be caused by species-specific properties of antibacterial immune responses. As histopathological lesions of human rhombencephalitis caused by LM strongly resemble those of ruminants, the disease likely has a similar pathogenesis in both hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.