ArticleThe Journal of infectious diseases2009
Epidemiological evidence for the role of the hemoglobin receptor, hmbR, in meningococcal virulence.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Complete genome and methylome analysis of Neisseria meningitidis associated with increased serogroup Y disease.Scientific reports · 2020Article
- A phylogenetic method to perform genome-wide association studies in microbes that accounts for population structure and recombination.PLoS computational biology · 2018Article
- The Impact of Nucleotide Sequence Analysis on Meningococcal Vaccine Development and Assessment.Frontiers in immunology · 2018Review
- A journey into the brain: insight into how bacterial pathogens cross blood-brain barriers.Nature reviews. Microbiology · 2017Review
- Heme Synthesis and Acquisition in Bacterial Pathogens.Journal of molecular biology · 2016Review
- Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: implications for gene regulation and virulence.Scientific reports · 2016Article
- Article
- Spectroscopic evidence for a 5-coordinate oxygenic ligated high spin ferric heme moiety in the Neisseria meningitidis hemoglobin binding receptor.Biochimica et biophysica acta · 2014Article
- Complete Genome Sequence of Neisseria meningitidis Serogroup A Strain NMA510612, Isolated from a Patient with Bacterial Meningitis in China.Genome announcements · 2014Article
- Genomic and global approaches to unravelling how hypermutable sequences influence bacterial pathogenesis.Pathogens (Basel, Switzerland) · 2014Review
- Characterizing the genetic basis of bacterial phenotypes using genome-wide association studies: a new direction for bacteriology.Genome medicine · 2014Article
- Distribution and diversity of the haemoglobin-haptoglobin iron-acquisition systems in pathogenic and non-pathogenic Neisseria.Microbiology (Reading, England) · 2013Article
- Article
- An analysis of the sequence variability of meningococcal fHbp, NadA and NHBA over a 50-year period in the Netherlands.PloS one · 2013Article
- Article
- Evolutionary and genomic insights into meningococcal biology.Future microbiology · 2012Review
- Influence of the combination and phase variation status of the haemoglobin receptors HmbR and HpuAB on meningococcal virulence.Microbiology (Reading, England) · 2011Article
- Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06.BMC genomics · 2010Article
- Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence.Journal of bacteriology · 2010Article
- Variation and molecular evolution of HmbR, the Neisseria meningitidis haemoglobin receptor.Microbiology (Reading, England) · 2010Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.