Evidence map›Paper›PMID 19476290›Full record

ReviewReviews on environmental health

Neurotoxic effects and biomarkers of lead exposure: a review.

Talia Sanders, Yiming Liu, Virginia Buchner, Paul B Tchounwou

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reviews on environmental health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05855096 (Clinical Assessment And Treatment Preferences of Physiotherapists Working in Neurorehabilitation), which is not on this map. Cited by 350 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
350citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05855096 completednot on this map

Clinical Assessment And Treatment Preferences of Physiotherapists Working in Neurorehabilitation: A Research From Turkey

TypeobservationalSponsorBiruni UniversityRan2023 to 2023Enrolled95ConditionsNeurorehabilitation, Physiotherapist, Clinical Assessment, Treatment PreferencesArmsGoogle Form Questionnaire
3 · Its place in the literature

Who cites it

350 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. A Systematic Review and Meta-analysis of Chemical Exposures and Attention-Deficit/Hyperactivity Disorder in Children.Prevention science : the official journal of the Society for Prevention Research · 2024
    Pooled it
  4. Human tissue lead (Pb) levels and amyotrophic lateral sclerosis: a systematic review and meta-analysis of case-control studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  5. Pooled it
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290 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Talia SandersMolecular Toxicology Research Laboratory, NIH RCMI - Center for Environmental Health, College of Science, Engineering, and Technology, Jackson State University, Jackson, MS, USA.
Yiming Liu
Virginia Buchner
Paul B Tchounwou

Funding

TRANSCRIPTOMICS OF GIARDIA LAMBLIAG12RR013459 · NCRR · JACKSON STATE UNIVERSITY · PI TCHOUNWOU, PAUL B. · 1998 to 2011
$18.0M
NCRR NIH HHS 2G12RR13459-11NCRR NIH HHS G12 RR013459
6 · The paper itself

Abstract

Lead, a systemic toxicant affecting virtually every organ system, primarily affects the central nervous system, particularly the developing brain. Consequently, children are at a greater risk than adults of suffering from the neurotoxic effects of lead. To date, no safe lead-exposure threshold has been identified. The ability of lead to pass through the blood-brain barrier is due in large part to its ability to substitute for calcium ions. Within the brain, lead-induced damage in the prefrontal cerebral cortex, hippocampus, and cerebellum can lead to a variety of neurologic disorders. At the molecular level, lead interferes with the regulatory action of calcium on cell functions and disrupts many intracellular biological activities. Experimental studies have also shown that lead exposure may have genotoxic effects, especially in the brain, bone marrow, liver, and lung cells. Knowledge of the neurotoxicology of lead has advanced in recent decades due to new information on its toxic mechanisms and cellular specificity. This paper presents an overview, updated to January 2009, of the neurotoxic effects of lead with regard to children, adults, and experimental animals at both cellular and molecular levels, and discusses the biomarkers of lead exposure that are useful for risk assessment in the field of environmental health.

Indexed as

Lead Poisoning, Nervous SystemAnimalsBiomarkersHumansLeadNeurotoxicity SyndromesSister Chromatid ExchangeBiomarkersLead

Identifiers

PMID19476290
PMCPMC2858639

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.