Trial reportAnnals of neurology2009
Remission of epilepsy after two drug failures in children: a prospective study.
Trial report in Annals of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association meta-analyses of drug-resistant epilepsy.EBioMedicine · 2025Pooled it
- Article
- Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis.EClinicalMedicine · 2022Article
- Article
- Pharmacovigilance in Pediatric Patients with Epilepsy Using Antiepileptic Drugs.International journal of environmental research and public health · 2022Article
- Felbamate for pediatric epilepsy-should we keep on using it as the last resort?Frontiers in neurology · 2022Article
- Different Prognostic Patterns in Epilepsies and Considerations About the Denotations of Atypical Patterns.Noro psikiyatri arsivi · 2022Review
- Pediatric Epilepsy Surgery: Indications and Evaluation.Indian journal of pediatrics · 2021Review
- Over 10-Year Outcomes of Infantile-Onset Epilepsies.Journal of clinical medicine · 2021Article
- Prospective validation of a machine learning model that uses provider notes to identify candidates for resective epilepsy surgery.Epilepsia · 2020Article
- A Review of Neurostimulation for Epilepsy in Pediatrics.Brain sciences · 2019Review
- Validated outcome of treatment changes according to International League Against Epilepsy criteria in adults with drug-resistant focal epilepsy.Epilepsia · 2019Observational
- Antiepileptic Drug Therapy in Patients with Drug-Resistant Epilepsy.Journal of epilepsy research · 2019Review
- Drug-resistant epilepsy in Indian children at a tertiary-care public hospital.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- A Retrospective Analysis of the Long-Term Outcome of Drug-Resistant Epilepsy in Children Treated in Urban India.Child neurology open · 2018Article
- Observational
- Old versus New: Why Do We Need New Antiepileptic Drugs?Journal of epilepsy research · 2014Review
- Complete remission of childhood-onset epilepsy: stability and prediction over two decades.Brain : a journal of neurology · 2014Article
- Surgical management of epilepsy.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Review
- Yield of epileptiform electroencephalogram abnormalities in incident unprovoked seizures: a population-based study.Epilepsia · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
objectiveDetermine the probability of a more than 1-year remission after failure of a second drug in children prospectively followed from initial diagnosis of epilepsy and then from time of second drug failure. Identify prognostic factors for remission after second drug failure.
methodsOf 613 children, 128 did not respond favorably to 2 drugs, had a trial of at least a third drug (median, 3), and were followed for more than 1 year (median, 10.1 years) since second drug failure. Product limit and proportional hazards techniques were used to analyze predictors of any 1-year remission (Rem1) and 1- and 3-year remission at last contact (Rem1/3-LC).
resultsSeventy-three patients (57%) had a remission. Repeated remissions and relapses were common. Only 48 (37.5%) achieved Rem1-LC and 28 (23%) Rem3-LC. Idiopathic epilepsy (Rem1: rate ratio [RR], 3.64, p < 0.0001; Rem1-LC: RR, 2.57, p = 0.008) and seizure frequency (Rem1: RR, 0.76, p = 0.003; Rem1-LC: RR, 0.82, p = 0.04 per increase in category) were the most robust predictors. Symptomatic cause was the only correlate of Rem3-LC. Remission before second drug failure did not predict remission after second drug failure.
interpretationRemission after second drug failure is common but often temporary. Children who have not responded to two appropriate drugs should be carefully evaluated to maximize therapy and possibly considered for more aggressive treatments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.