Evidence map›Paper›PMID 19475542›Full record

ReviewAmerican journal of primatology2009

Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause.

Mary Lou Voytko, Gregory Paul Tinkler, Carole Browne, Joseph R Tobin

Abstract readReview
In one paragraph

Review in American journal of primatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021
    Review
  7. Article
  8. Article
  9. Hormonal Influences on Cognitive Function.The Malaysian journal of medical sciences : MJMS · 2018
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Clinically relevant hormone treatments fail to induce spinogenesis in prefrontal cortex of aged female rhesus monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012
    Article
  16. Effects of a Chinese medicinal plant Radix astragali on the ovariectomized female rats.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2012
    Article
  17. Hormone replacement therapy and risk for neurodegenerative diseases.International journal of Alzheimer's disease · 2012
    Article
  18. Review
  19. Immune senescence in aged nonhuman primates.Experimental gerontology · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mary Lou VoytkoDepartment of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. mlvoytko@wfubmc.edu
Gregory Paul Tinkler
Carole Browne
Joseph R Tobin

Funding

Cognition and Estrogen in Menopause:A Monkey ModelR01AG013204 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VOYTKO, MARY LOU · 2002 to 2006
$3.0M
COGNITION AND ESTROGEN IN MENOPAUSER29AG013204 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VOYTKO, MARY LOU · 1996 to 2000
$92k
NIA NIH HHS R01 AG013204NIA NIH HHS R29 AG013204
6 · The paper itself

Abstract

Many postmenopausal women question whether to start or continue hormone therapy because of recent clinical trial negative results. However, evidence from other studies of postmenopausal women, and from studies in menopausal monkeys, indicate that estrogen has neurocognitive protective effects, particularly when therapy is initiated close to the time of menopause before neural systems become increasingly compromised with age. In this review, we present studies of menopausal women and female monkeys that support the concept that estrogen therapies protect both cognitive function and neurobiological processes.

Indexed as

Models, AnimalAge FactorsAnimalsBrainCognitionEstrogen Replacement TherapyEstrogensFemaleHumansMenopauseNeuroprotective AgentsReceptors, NeurotransmitterSynapsesEstrogensNeuroprotective AgentsReceptors, Neurotransmitter

Identifiers

PMID19475542
PMCPMC2847862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.