ReviewPflugers Archiv : European journal of physiology2009
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
Review in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- NAADP-Evoked CaInternational journal of molecular sciences · 2023Article
- Genome-wide investigation and expression analysis ofFrontiers in plant science · 2023Article
- Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging.Handbook of experimental pharmacology · 2023Article
- Identification of OSCA gene family in Solanum habrochaites and its function analysis under stress.BMC genomics · 2022Article
- Deepening the Whole Transcriptomics of Bovine Liver Cells Exposed to AFB1: A Spotlight on Toll-like Receptor 2.Toxins · 2022Article
- Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease.Autophagy · 2022Article
- NAADP receptors: A one-two.Cell calcium · 2021Article
- CD38 in the age of COVID-19: a medical perspective.Physiological reviews · 2021Review
- Review
- Membrane transport proteins in melanosomes: Regulation of ions for pigmentation.Biochimica et biophysica acta. Biomembranes · 2020Review
- Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory.Behavior genetics · 2020Article
- Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation.Cold Spring Harbor perspectives in biology · 2020Review
- The Interplay between CaInternational journal of molecular sciences · 2019Review
- NAADP Receptors.Cold Spring Harbor perspectives in biology · 2019Review
- Article
- The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.Scientific reports · 2017Article
- Voltage-gated calcium channels: Novel targets for cancer therapy.Oncology letters · 2017Article
- Deviant lysosomal CaMessenger (Los Angeles, Calif. : Print) · 2016Article
- Biophysical Adaptations of Prokaryotic Voltage-Gated Sodium Channels.Current topics in membranes · 2016Article
- Two-Pore Channels: Lessons from Mutant Mouse Models.Messenger (Los Angeles, Calif. : Print) · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca(2+) mobilisation. In addition, we describe how TPCs may also trigger further Ca(2+) release by coupling to the endoplasmic reticular stores through activation of IP(3) receptors and ryanodine receptors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.