ArticleThe Analyst2009
Detection of breast micro-metastases in axillary lymph nodes by infrared micro-spectral imaging.
Article in The Analyst, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 72 citations in OpenAlex.
- Trial
- Artificial Intelligence-Assisted Infrared Spectroscopy and Chemometrics for Enhanced Histopathology Screening of Micro- and Macrocancer Lesions.Analytical chemistry · 2026Article
- Scientific Advances in Cancer Detection Using Raman Spectroscopy.Asian Pacific journal of cancer prevention : APJCP · 2024Review
- HistoPerm: A permutation-based view generation approach for improving histopathologic feature representation learning.Journal of pathology informatics · 2023Article
- Statistical Considerations and Tools to Improve Histopathologic Protocols with Spectroscopic Imaging.Applied spectroscopy · 2022Article
- Infrared-spectroscopic, dynamic near-field microscopy of living cells and nanoparticles in water.Scientific reports · 2021Article
- Interrogation ofCancers · 2020Article
- Vibrational Spectroscopy for Identification of Metabolites in Biologic Samples.Molecules (Basel, Switzerland) · 2020Review
- The mechanical responses of advecting cells in confined flow.Biomicrofluidics · 2020Review
- Applications of hyperspectral imaging in the detection and diagnosis of solid tumors.Translational cancer research · 2020Review
- An Innovative Platform Merging Elemental Analysis and Ftir Imaging for Breast Tissue Analysis.Scientific reports · 2019Article
- A comparison of mid-infrared spectral regions on accuracy of tissue classification.The Analyst · 2019Article
- Deep learning for FTIR histology: leveraging spatial and spectral features with convolutional neural networks.The Analyst · 2019Article
- Resolving Interobserver Discrepancies in Lung Cancer Diagnoses by Spectral Histopathology.Archives of pathology & laboratory medicine · 2019Article
- Using Fourier transform IR spectroscopy to analyze biological materials.Nature protocols · 2014Article
- Grading of intrinsic and acquired cisplatin-resistant human melanoma cell lines: an infrared ATR study.European biophysics journal : EBJ · 2011Article
- Distinguishing cell types or populations based on the computational analysis of their infrared spectra.Nature protocols · 2010Article
- Non-invasive, Contrast-enhanced Spectral Imaging of Breast Cancer Signatures in Preclinical Animal Models In vivo.Journal of cell science & therapy · 2010Article
- Spectral detection of micro-metastases in lymph node histo-pathology.Journal of biophotonics · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We report the ability of infrared micro-spectral imaging, coupled with completely unsupervised methods of multivariate statistical analysis, to accurately reproduce the histological architecture of axillary lymph nodes and detect metastatic breast cancer cells. The acquisition of spectral data from tissue embedded in paraffin provided spectra free of dispersive artefacts that may be observed for infrared microscopic measurements using a 'reflection/absorption' methodology. As a consequence, superior tissue classification and identification of cellular abnormality unattainable for deparaffinised tissue was achieved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.