Evidence map›Paper›PMID 19474799›Full record

ArticleLeukemia2009

Identification of MNDA as a new marker for nodal marginal zone lymphoma.

G Kanellis, G Roncador, A Arribas, M Mollejo, S Montes-Moreno, L Maestre, Y Campos-Martin, J L Ríos Gonzalez, J L Martinez-Torrecuadrada, L Sanchez-Verde and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Leukemic-phase mucosa-associated lymphoid tissue lymphoma.International journal of hematology · 2023
    Article
  10. Review
  11. Follicular lymphoma and marginal zone lymphoma: how many diseases?Virchows Archiv : an international journal of pathology · 2023
    Review
  12. Article
  13. Review
  14. Relevance of Additional Immunohistochemical Markers in the Differential Diagnosis of Small B-Cell Lymphomas: A Case-Control StudyTurkish journal of haematology : official journal of Turkish Society of Haematology · 2022
    Article
  15. Article
  16. DNA Methylation-Derived Immune Cell Profiles, CpG Markers of Inflammation, and Pancreatic Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  17. Article
  18. The Pathogenic Effects ofFrontiers in cell and developmental biology · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

G KanellisMolecular Pathology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
G Roncador
A Arribas
M Mollejo
S Montes-Moreno
L Maestre
Y Campos-Martin
J L Ríos Gonzalez
J L Martinez-Torrecuadrada
L Sanchez-Verde
R Pajares
J C Cigudosa
M C Martin
M A Piris
Spanish National Cancer Research Centre · ESHospital Virgen de la Salud · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical and biological studies on nodal marginal zone lymphoma (NMZL) are hampered by the lack of specific diagnostic markers and the low reproducibility of this diagnosis. A comparative expression-profiling study has shown a set of markers to be differentially expressed in NMZL compared with follicular lymphoma (FL), including myeloid cell nuclear differentiation antigen (MNDA), a nuclear protein expressed by myeloid cells and a subset of B-cells. The aim of this study was to characterize the expression of MNDA in normal and reactive human tissue, and in a large series of non-Hodgkin's B-cell lymphomas, with particular emphasis on NMZL and FL. Our results showed that MNDA is expressed in normal tissue by a subset of the marginal zone B cells. They also showed MNDA expression in subgroups of chronic lymphocytic leukemia, mantle-cell lymphoma, and diffuse large B-cell lymphoma, but MNDA was especially expressed by lymphomas derived from the marginal zone, such as mucosa-associated lymphoid-tissue lymphoma, splenic marginal-zone lymphoma and NMZL. MNDA expression was rarely observed in FL, a characteristic that is of potential value in distinguishing between NMZL and FL. MNDA expression is thus a useful tool for the recognition of NMZL.

Indexed as

AnimalsAntigens, Differentiation, MyelomonocyticBiomarkers, TumorBlotting, WesternFluorescent Antibody TechniqueGene Expression ProfilingHumansImmunoenzyme TechniquesImmunoglobulin GIn Situ Hybridization, FluorescenceLymphoma, B-Cell, Marginal ZoneLymphoma, FollicularMiceMice, Inbred BALB COligonucleotide Array Sequence AnalysisPrognosisAntigens, Differentiation, MyelomonocyticBiomarkers, TumorImmunoglobulin GMNDA protein, humanTranscription Factors

Identifiers

PMID19474799
OpenAlexW2022200351

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.