ArticleAlzheimer disease and associated disorders
High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Technical and clinical validation of commercial automated volumetric MRI tools for dementia diagnosis-a systematic review.Neuroradiology · 2021Pooled it
- Translating research findings into clinical practice: a systematic and critical review of neuroimaging-based clinical tools for brain disorders.Translational psychiatry · 2020Pooled it
- Structural magnetic resonance imaging for the early diagnosis of dementia due to Alzheimer's disease in people with mild cognitive impairment.The Cochrane database of systematic reviews · 2020Pooled it
- Combination of automated brain volumetry on MRI and quantitative tau deposition on THK-5351 PET to support diagnosis of Alzheimer's disease.Scientific reports · 2021Trial
- A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.Neurology · 2015Trial
- Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial.Archives of neurology · 2012Trial
- Multi-threshold polygenic risk improves hippocampal-based cognitive decline prediction.Genome medicine · 2026Article
- Sex-dependent grey matter atrophy in Alzheimer's disease progression.Brain communications · 2026Article
- Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review.Frontiers in oncology · 2024Review
- Baseline structural MRI and plasma biomarkers predict longitudinal structural atrophy and cognitive decline in early Alzheimer's disease.Alzheimer's research & therapy · 2023Article
- Loss of corneal nerves and brain volume in mild cognitive impairment and dementia.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuantFrontiers in human neuroscience · 2022Review
- Patterns of structure-function association in normal aging and in Alzheimer's disease: Screening for mild cognitive impairment and dementia with ML regression and classification models.Frontiers in aging neuroscience · 2022Article
- Bayesian inference and dynamic prediction of multivariate joint model with functional data: An application to Alzheimer's disease.Statistics in medicine · 2021Article
- Conductance-Based Structural Brain Connectivity in Aging and Dementia.Brain connectivity · 2021Article
- Role of hippocampal location and radiation dose in glioblastoma patients with hippocampal atrophy.Radiation oncology (London, England) · 2021Article
- Evaluation of Reproducibility of Brain Volumetry between Commercial Software, Inbrain and Established Research Purpose Method, FreeSurfer.Journal of clinical neurology (Seoul, Korea) · 2021Article
- Comparison of Automated Brain Volume Measures by NeuroQuant vs. Freesurfer in Patients with Mild Cognitive Impairment: Effect of Slice Thickness.Yonsei medical journal · 2021Article
- Corpus Callosum Atrophy in Detection of Mild and Moderate Alzheimer's Disease Using Brain Magnetic Resonance Image Processing and Machine Learning Techniques.Journal of Alzheimer's disease reports · 2021Article
- BrainFD: Measuring the Intracranial Brain Volume With Fractal Dimension.Frontiers in aging neuroscience · 2021Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Medial temporal lobe (MTL) atrophy is associated with increased risk for conversion to Alzheimer disease, but manual tracing techniques and even semiautomated techniques for volumetric assessment are not practical in the clinical setting. In addition, most studies that examined MTL atrophy in Alzheimer disease have focused only on the hippocampus. It is unknown the extent to which volumes of amygdala and temporal horn of the lateral ventricle predict subsequent clinical decline. This study examined whether measures of hippocampus, amygdala, and temporal horn volume predict clinical decline over the following 6-month period in patients with mild cognitive impairment (MCI). Fully automated volume measurements were performed in 269 MCI patients. Baseline volumes of the hippocampus, amygdala, and temporal horn were evaluated as predictors of change in Mini-mental State Examination and Clinical Dementia Rating Sum of Boxes over a 6-month interval. Fully automated measurements of baseline hippocampus and amygdala volumes correlated with baseline delayed recall scores. Patients with smaller baseline volumes of the hippocampus and amygdala or larger baseline volumes of the temporal horn had more rapid subsequent clinical decline on Mini-mental State Examination and Clinical Dementia Rating Sum of Boxes. Fully automated and rapid measurement of segmental MTL volumes may help clinicians predict clinical decline in MCI patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.