ArticleNucleic acids research2009
Methylation detection oligonucleotide microarray analysis: a high-resolution method for detection of CpG island methylation.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- A quantitative proteomics-based signature of platinum sensitivity in ovarian cancer cell lines.The Biochemical journal · 2015Article
- Epigenetic determinants of ovarian clear cell carcinoma biology.International journal of cancer · 2014Article
- Evidence for a Functional Link between Chromosomal Breakpoints and Aberrant DNA Methylation in Cancer.Frontiers in oncology · 2014Article
- Major chromosomal breakpoint intervals in breast cancer co-localize with differentially methylated regions.Frontiers in oncology · 2012Article
- DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables.Molecular oncology · 2011Article
- Systematic evaluation of genome-wide methylated DNA enrichment using a CpG island array.BMC genomics · 2011Article
- Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancer.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
Methylation of CpG islands associated with genes can affect the expression of the proximal gene, and methylation of non-associated CpG islands correlates to genomic instability. This epigenetic modification has been shown to be important in many pathologies, from development and disease to cancer. We report the development of a novel high-resolution microarray that detects the methylation status of over 25,000 CpG islands in the human genome. Experiments were performed to demonstrate low system noise in the methodology and that the array probes have a high signal to noise ratio. Methylation measurements between different cell lines were validated demonstrating the accuracy of measurement. We then identified alterations in CpG islands, both those associated with gene promoters, as well as non-promoter-associated islands in a set of breast and ovarian tumors. We demonstrate that this methodology accurately identifies methylation profiles in cancer and in principle it can differentiate any CpG methylation alterations and can be adapted to analyze other species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.