ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Subthreshold glutamate release from mitral cell dendrites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Getting Graded: Teaching Principles of Chemical Synaptic Transmission Without Action Potentials.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2021Article
- Diversity of Axonal and Dendritic Contributions to Neuronal Output.Frontiers in cellular neuroscience · 2019Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- And yet it moves: Recovery of volitional control after spinal cord injury.Progress in neurobiology · 2018Review
- Synchronous Infra-Slow Bursting in the Mouse Accessory Olfactory Bulb Emerge from Interplay between Intrinsic Neuronal Dynamics and Network Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Impact of Transcranial Direct Current Stimulation (tDCS) on Neuronal Functions.Frontiers in neuroscience · 2016Review
- Presynaptic T-type Ca2+ channels modulate dendrodendritic mitral-mitral and mitral-periglomerular connections in mouse olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Regenerative glutamate release by presynaptic NMDA receptors contributes to spreading depression.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Calcium-activated sustained firing responses distinguish accessory from main olfactory bulb mitral cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Local dendrodendritic inhibition regulates fast synaptic transmission in visual thalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Functional polarity in neurons: what can we learn from studying an exception?Current opinion in neurobiology · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The dendrites of a number of neuron types function as presynaptic structures, releasing transmitter after action potentials and dendritic spikes. In this regard, dendrites can function like axons, producing discrete outputs after suprathreshold electrical events. However, as the major site of synaptic inputs, dendrites experience ongoing subthreshold fluctuations in membrane potential, raising the question of whether these subthreshold changes can cause changes in transmitter release. Here, we show that mitral cells of the accessory olfactory bulb release glutamate from their dendrites in response to both subthreshold and suprathreshold stimuli. Whereas subthreshold output was typically low under control conditions, it could be enhanced several fold by pharmacological or endogenous activation of group I metabotropic glutamate receptors. These results indicate that presynaptic dendrites can support two distinct forms of output, and can dynamically regulate how electrical activity is coupled to transmitter release.
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Registered trials
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