ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Membrane potential changes in dendritic spines during action potentials and synaptic input.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 147 citations in OpenAlex.
- Highly attenuated dendritic propagation of isolated synaptic potentials in vivo.Science advances · 2026Article
- How to train your neuron: developing a detailed, up-to-date, multipurpose model of hippocampal CA1 pyramidal cells.Frontiers in computational neuroscience · 2026Article
- Contribution of individual excitatory synapses on dendritic spines to electrical signaling.Frontiers in neuroscience · 2025Article
- The plasticity of pyramidal neurons in the behaving brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Glial KCNQ KNeuron · 2024Article
- Neuron with well-designed ionic system.Biophysics and physicobiology · 2024Article
- Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines.eLife · 2023Article
- Electrical properties of dendritic spines.Biophysical journal · 2023Review
- Excitation-transcription coupling, neuronal gene expression and synaptic plasticity.Nature reviews. Neuroscience · 2023Review
- A GPU-based computational framework that bridges neuron simulation and artificial intelligence.Nature communications · 2023Article
- Current Practice in Using Voltage Imaging to Record Fast Neuronal Activity: Successful Examples from Invertebrate to Mammalian Studies.Biosensors · 2023Review
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Electrophysiology of Dendritic Spines: Information Processing, Dynamic Compartmentalization, and Synaptic Plasticity.Advances in neurobiology · 2023Article
- Voltage compartmentalization in dendritic spines in vivo.Science (New York, N.Y.) · 2022Article
- Electrical recordings from dendritic spines of adult mouse hippocampus and effect of the actin cytoskeleton.Frontiers in molecular neuroscience · 2022Article
- The glutamatergic synapse: a complex machinery for information processing.Cognitive neurodynamics · 2021Review
- Measuring Absolute Membrane Potential Across Space and Time.Annual review of biophysics · 2021Review
- Modeling Neurotransmission: Computational Tools to Investigate Neurological Disorders.International journal of molecular sciences · 2021Review
- Synaptic dendritic activity modulates the single synaptic event.Cognitive neurodynamics · 2021Article
- Spatio-temporal parameters for optical probing of neuronal activity.Biophysical reviews · 2021Review
24 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excitatory input onto many neurons in the brain occurs onto specialized projections called dendritic spines. Despite their potential importance in neuronal function, direct experimental evidence on electrical signaling in dendritic spines is lacking as their small size makes them inaccessible to standard electrophysiological techniques. Here, we investigate electrical signaling in dendritic spines using voltage-sensitive dye imaging in cortical pyramidal neurons during backpropagating action potentials and synaptic input. Backpropagating action potentials were found to fully invade dendritic spines without voltage loss. The voltage change in dendritic spines during synaptic input ranged from a few millivolts up to approximately 20 mV. During hyperpolarization of the membrane potential, the amplitude of the synaptic voltage in spines was increased, consistent with the expected change resulting from the increased driving force. This observation suggests that voltage-activated channels do not significantly boost the voltage response in dendritic spines during synaptic input. Finally, we used simulations of our experimental observations in morphologically realistic models to estimate spine neck resistance. These simulations indicated that spine neck resistance ranges up to approximately 500 Mohms. Spine neck resistances of this magnitude reduce somatic EPSPs by <15%, indicating that the spine neck is unlikely to act as a physical device to significantly modify synaptic strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.